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Comment
. 2022 Mar 3;82(5):889-890.
doi: 10.1016/j.molcel.2022.02.012.

Releasing the trap: How the segregase p97 extracts PARP1 from chromatin

Maximilian J Götz  1 , Julian Stingele  2
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Comment

Releasing the trap: How the segregase p97 extracts PARP1 from chromatin

Maximilian J Götz et al. Mol Cell. .
Free article

Abstract

Krastev et al. (2022) identify a cellular mechanism that counteracts cytotoxic trapping of PARP1 induced by clinical PARP inhibitors. SUMO-targeted ubiquitylation of trapped PARP1 is shown to trigger the enzymes' extraction from chromatin by the p97 ATPase.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
    Krastev DB, Li S, Sun Y, Wicks AJ, Hoslett G, Weekes D, Badder LM, Knight EG, Marlow R, Pardo MC, Yu L, Talele TT, Bartek J, Choudhary JS, Pommier Y, Pettitt SJ, Tutt ANJ, Ramadan K, Lord CJ. Krastev DB, et al. Nat Cell Biol. 2022 Jan;24(1):62-73. doi: 10.1038/s41556-021-00807-6. Epub 2022 Jan 10. Nat Cell Biol. 2022. PMID: 35013556 Free PMC article.

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