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Comment
. 2022 Mar 3;29(3):352-354.
doi: 10.1016/j.stem.2022.02.002.

T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR

Ronald J Vagnozzi  1 , Timothy A McKinsey  2
Affiliations
Free article
Comment

T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR

Ronald J Vagnozzi et al. Cell Stem Cell. .
Free article

Abstract

Fibrosis, or chronic fibroblast activation and extracellular matrix deposition, underlies most cardiovascular diseases and remains challenging to target therapeutically. Reported in Science by Rurik et al., modified mRNA technology can reprogram endogenous T cells into fibroblast-ablating CAR-Ts in mouse hearts, offering a promising and tractable immunotherapy approach for tackling fibrosis.

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Conflict of interest statement

Declaration of interests T.A.M. is on the scientific advisory boards of Artemes Bio and Eikonizo Therapeutics, received funding from Italfarmaco for an unrelated project, and has a subcontract from Eikonizo Therapeutics related to an SBIR grant from the National Institutes of Health (HL154959).

Comment on

  • CAR T cells produced in vivo to treat cardiac injury.
    Rurik JG, Tombácz I, Yadegari A, Méndez Fernández PO, Shewale SV, Li L, Kimura T, Soliman OY, Papp TE, Tam YK, Mui BL, Albelda SM, Puré E, June CH, Aghajanian H, Weissman D, Parhiz H, Epstein JA. Rurik JG, et al. Science. 2022 Jan 7;375(6576):91-96. doi: 10.1126/science.abm0594. Epub 2022 Jan 6. Science. 2022. PMID: 34990237 Free PMC article.

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