Quo vadis, neutrophil?

Rodrigo J Gonzalez¹, Ulrich H von Andrian²

Affiliations

¹ Department of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
² Department of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Electronic address: uva@hms.harvard.edu.

PMID: 35245478
DOI: 10.1016/j.cell.2022.02.009

Comment

Quo vadis, neutrophil?

Rodrigo J Gonzalez et al. Cell. 2022.

. 2022 Mar 3;185(5):759-761.

doi: 10.1016/j.cell.2022.02.009.

Authors

Rodrigo J Gonzalez¹, Ulrich H von Andrian²

Affiliations

¹ Department of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
² Department of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Electronic address: uva@hms.harvard.edu.

PMID: 35245478
DOI: 10.1016/j.cell.2022.02.009

Abstract

Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues.

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Conflict of interest statement

Declaration of interests Ulrich H. von Andrian is a founder of Selecta Biosciences and of Monopteros Biotherapeutics and a member of both companies’ scientific advisory boards. He is also a member of the scientific advisory boards of Avenge Bio, Beam Therapeutics, Bluesphere Bio, Cygnal, Evelo, Intergalactic, Interon, Mallinckrodt Pharmaceutical, Moderna, Morphic Therapeutics, Rubius, and SQZ.

Comment on

GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.
De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. De Giovanni M, et al. Cell. 2022 Mar 3;185(5):815-830.e19. doi: 10.1016/j.cell.2022.01.010. Epub 2022 Feb 10. Cell. 2022. PMID: 35148838 Free PMC article.

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Quo vadis, neutrophil?

Affiliations

Quo vadis, neutrophil?

Authors

Affiliations

Abstract

Conflict of interest statement

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Publication types

MeSH terms