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Review
. 2022 Apr:166:94-97.
doi: 10.1016/j.lungcan.2022.02.006. Epub 2022 Feb 18.

EGFR-RAD51 fusion in lung adenocarcinoma with systemic and intracranial response to osimertinib: A case report and review of the literature

Rubens Copia Sperandio  1 , Francinne Luiza Teixeira Tostes  1 , Paulo Vidal Campregher  1 , Vitor Ribeiro Paes  1 , Fernando Moura  1 , Gustavo Schvartsman  2
Affiliations
Review

EGFR-RAD51 fusion in lung adenocarcinoma with systemic and intracranial response to osimertinib: A case report and review of the literature

Rubens Copia Sperandio et al. Lung Cancer. 2022 Apr.

Abstract

Comprehensive next-generation sequencing panels are leading to detection of rare gene fusion events. EFGR-RAD51 fusion is a rare oncogenic finding and clinical data for management of this condition is scarce. We report a widely metastatic non-small cell lung cancer in a never-smoker young male patient with sustained near-complete systemic and intracranial response to osimertinib, a third-generation EGFR tyrosine-kinase inhibitor (TKI). We also review the available data of other TKIs in this scenario and underscore the role of comprehensive molecular testing for NSCLC.

Keywords: Gene fusions; Molecular targeted therapy; Molecular testing; Non-small cell lung cancer.

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