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. 2022 Mar 4;8(1):15.
doi: 10.1186/s40942-021-00351-3.

Retinal and choroidal thickness in pediatric patients with sickle cell disease: a cross-sectional cohort study

Juliana Prazeres  1 , Luiz Filipe Lucatto  1 , Adriano Ferreira  1 , Nilva Moraes  1 , Josefina A P Braga  2 , Luiz H Lima  1 , Caio Regatieri  1 , Maurício Maia  3
Affiliations

Retinal and choroidal thickness in pediatric patients with sickle cell disease: a cross-sectional cohort study

Juliana Prazeres et al. Int J Retina Vitreous. .

Abstract

Background: To measure the retinal/choroidal thicknesses in the macular area of asymptomatic pediatric patients with sickle cell disease (SCD).

Methods: This cross-sectional cohort study included 40 children (79 eyes) with SCD and 19 control patients (36 eyes). All subjects underwent spectral-domain optical coherence tomography (SD-OCT) with enhanced-depth imaging OCT. Generalized Estimating Equations (GEE) were applied to compare the outcomes between groups. P ≤ 0.05 was considered significant.

Results: The choroidal thickness in the macular area in the study subfields was significantly thinner in the SCD eyes compared with control eyes (subfoveal subfield and temporal parafoveal subfield, p < 0.0001; nasal parafoveal subfield, p < 0.0001 temporal perifoveal subfield, p < 0.0001; and nasal perifoveal subfield, p < 0.0001). The variations in the retinal thickness were not significant.

Conclusion: EDI-OCT showed that the macular choroidal thickness is thinner in asymptomatic pediatric patients with SCD.

Keywords: Choroidal thickness; Retinal thickness; Sickle cell disease.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
An EDI-OCT scan from one study patient. The choroidal thickness was measured perpendicularly from the outer edge of the retinal pigment epithelium to the chorioscleral boundary at five points: subfoveal, nasal perifoveal (500 µm nasal to the fovea), nasal perifoveal (1000 µm nasal to the fovea), temporal perifoveal (500 μm temporal to the fovea), and temporal parafoveal (1000 μm temporal to the fovea)
Fig. 2
Fig. 2
Comparison of retinal thickness subfield measurements between the SCD and control groups. The subfoveal choroidal thickness is 240.78 ± 21.27, and the mean foveal retinal thickness is 256.39 ± 20.84. There is no significant reduction in the retinal thickness in the SCD group compared with the control eyes
Fig. 3
Fig. 3
Comparison of choroidal thickness measurements between the SCD and control groups. The choroidal thickness measurements decreased in the SCD eyes. Compared with the control eyes, the choroidal thickness measurements in the SCD eyes are decreased in the subfovea parafovea (p < 0.001) and temporal parafovea (p < 0.001), nasal parafovea (p < 0.01), temporal perifovea (p < 0.01), and nasal perifovea (p =  < 0.01)
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