Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May;16(5):460-471.
doi: 10.1002/term.3295. Epub 2022 Mar 4.

Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds

Tayyba Sher Waris  1 , Syed Tahir Abbas Shah  2 , Azra Mehmood  3 , Zohaib Iqbal  3 , Mubashra Zehra  1 , Aqif Anwar Chaudhry  1 , Ihtesham Ur Rehman  1   4 , Muhammad Yar  1
Affiliations

Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds

Tayyba Sher Waris et al. J Tissue Eng Regen Med. 2022 May.

Retraction in

Abstract

This research on a thyroxine/heparin-based cotton wound dressing tests angiogenic and wound healing ability of thyroxine/heparin in a chick chorionic allantoic membrane bioassay and in skin wounds in healthy rats. Commercially available cotton dressings were simply loaded with thyroxine/heparin solutions and coated with wax. Prior to undertaking the animal study, we assessed in vitro release of thyroxine/heparin from coated and uncoated cotton dressings. Both showed more than 85% release of drug over 14 days, though the lesser release was observed in wax-coated thyroxine/heparin dressing as compared to uncoated thyroxine/heparin dressing. Testing of angiogenesis through CAM assay proved good angiogenic potential of heparin and thyroxin, but the thyroxine found more angiogenic than heparin. In animal study, full-thickness skin wounds of 20 mm diameter showed good healing in both heparin and thyroxine-treated groups. But the most striking result was seen in the thyroxine-treated group where thyroxine showed significant difference with heparin-treated group and completely healed the wounds in 23 days. Thus, the study suggest that thyroxine possesses greater angiogenic and wound healing potential than heparin, and the use of thyroxine/heparin-loaded wax-coated cotton dressing could be a cost-effective option for the management of chronic wounds.

Keywords: CAM assay; angiogenesis; cotton dressing; tissue engineering; wound healing.

PubMed Disclaimer

References

REFERENCES

    1. Abdelrahman, T., & Newton, H. (2011). Wound dressings: Principles and practice. Surgery, 29(10), 491-495.
    1. Ahmed, A., Getti, G., & Boateng, J. (2021). Medicated multi-targeted alginate-based dressings for potential treatment of mixed bacterial-fungal infections in diabetic foot ulcers. International Journal of Pharmaceutics, 606, 120903.
    1. Ahtzaz, S., Waris, T. S., Shahzadi, L., Chaudhary, A. A., & Rehman, U. I. (2019). Boron for tissue regeneration - It’s loading into chitosan/collagen hydrogels and testing on chorioallantoic membrane to study the effect on angiogenesis. International Journal of Polymeric Materials and Polymeric Biomaterials, 69(8), 525-534.
    1. Albini, A., Benelli, A., Presta, M., Rusnati, M., Ziche, M., Rubartelli, A., Paglialunga, G., Bussolino, A., & Noonan, D. (1996). HIV-tat protein is a heparin-binding angiogenic growth factor. Oncogene, 12(2), 289-297.
    1. Aleem, A. R., Shahzadi, L., Alvi, F., Khan, A. F., Chaudhry, A. A., Rehman, U. I., & Yar, M. (2017). Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization. Materials & Design, 133, 416-425.

Publication types

LinkOut - more resources