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. 2022 Sep 30;75(7):1239-1241.
doi: 10.1093/cid/ciac186.

Real-World Incidence of Breakthrough Coronavirus Disease 2019 Hospitalization After Vaccination vs Natural Infection in a Large, Local, Empaneled Primary Care Population Using Time-to-Event Analysis

Benjamin D Pollock  1 , Curtis B Storlie  2 , Aaron J Tande  3 , Priya Sampathkumar  3
Affiliations

Real-World Incidence of Breakthrough Coronavirus Disease 2019 Hospitalization After Vaccination vs Natural Infection in a Large, Local, Empaneled Primary Care Population Using Time-to-Event Analysis

Benjamin D Pollock et al. Clin Infect Dis. .

Abstract

We followed 106 349 primary care patients for 22 385 3099 person-days across 21 calendar months and documented 69 breakthrough coronavirus disease 2019 (COVID-19) hospitalizations: 65/102,613 (0.06%) among those fully vaccinated, 3/11 047 (0.03%) among those previously infected, and 1/7,313 (0.01%) among those with both statuses. These data give providers real-world context regarding breakthrough COVID-19 hospitalization risk.

Keywords: COVID-19; breakthrough; natural immunity; vaccination.

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Conflict of interest statement

Potential conflicts of interest. A. J. T. reports receiving payment from UpToDate for writing a treatment section on osteomyelitis and reports playing an unpaid role as a board member for the Musculoskeletal Infection Society. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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