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Review
. 2022;269(1):435-455.
doi: 10.1016/bs.pbr.2022.01.016. Epub 2022 Feb 11.

Neuromodulation of cognition in Parkinson's disease

Rachel C Cole  1 , Derrick N Okine  1 , Brooke E Yeager  1 , Nandakumar S Narayanan  2
Affiliations
Review

Neuromodulation of cognition in Parkinson's disease

Rachel C Cole et al. Prog Brain Res. 2022.

Abstract

Neuromodulation is a widely used treatment for motor symptoms of Parkinson's disease (PD). It can be a highly effective treatment as a result of knowledge of circuit dysfunction associated with motor symptoms in PD. However, the mechanisms underlying cognitive symptoms of PD are less well-known, and the effects of neuromodulation on these symptoms are less consistent. Nonetheless, neuromodulation provides a unique opportunity to modulate motor and cognitive circuits while minimizing off-target side effects. We review the modalities of neuromodulation used in PD and the potential implications for cognitive symptoms. There have been some encouraging findings with both invasive and noninvasive modalities of neuromodulation, and there are promising advances being made in the field of therapeutic neuromodulation. Substantial work is needed to determine which modulation targets are most effective for the different types of cognitive deficits of PD.

Keywords: Basal ganglia; Deep brain stimulation; Movement disorders; Nonmotor symptoms; Prefrontal cortex; Transcranial alternating current stimulation; Transcranial direct current stimulation; Transcranial magnetic stimulation.

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Figures

FIG. 1
FIG. 1
Types of neuromodulation that might be useful for cognition in Parkinson’s disease.
FIG. 2
FIG. 2
Potential targets for neuromodulation that might improve cognition in Parkinson’s disease.
See this image and copyright information in PMC

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