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. 2022 May;128(5):e303-e305.
doi: 10.1016/j.bja.2022.01.033. Epub 2022 Mar 2.

Methodological issues in meta-analyses of observational studies: the need for attention to the details

Eduardo M H Padrão  1 , Hassan Rahhal  2 , Fernando S Valente  2 , Bruno A M P Besen  2
Affiliations

Methodological issues in meta-analyses of observational studies: the need for attention to the details

Eduardo M H Padrão et al. Br J Anaesth. 2022 May.
No abstract available

Keywords: COVID-19; awake prone positioning; meta-analysis; methodology; tracheal intubation.

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Figures

Fig 1
Fig 1
Forest plot of the hazard ratio for tracheal intubation among observational studies presenting adjusted estimates and the clinical trial. Estimates obtained from a random effects model using the Hartung–Knapp–Sidik–Jonkman method. APP, awake prone positioning; CI, confidence interval; HR, hazard ratio.
See this image and copyright information in PMC

Comment in

References

    1. Fazzini B., Page A., Pearse R., Puthucheary Z. Prone positioning for non-intubated spontaneously breathing patients with acute hypoxaemic respiratory failure: a systematic review and meta-analysis. Br J Anaesth. 2022;128:352–362. - PMC - PubMed
    1. Brown S.M., Duggal A., Hou P.C., et al. Nonlinear imputation of PaO2/FIO2 from SpO2/FIO2 among mechanically ventilated patients in the ICU: a prospective, observational study. Crit Care Med. 2017;45:1317–1324. - PMC - PubMed
    1. Reeves B.C., Deeks J.J., Higgins J.P.T., et al. In: Cochrane Handbook for systematic Reviews of interventions. Version 6.2. Cochrane. Higgins J.P.T., Thomas J., Chandler J., et al., editors. 2021. Chapter 24: including non-randomized studies on intervention effects.
    1. Hernán M.A. Causal analyses of existing databases: no power calculations required. J Clin Epidemiol. 2021 doi: 10.1016/j.jclinepi.2021.08.028. Advance Access published on August 27. - DOI - PMC - PubMed
    1. Padrão E.M.H., Valente F.S., Besen B.A.M.P., et al. Awake prone positioning in COVID-19 hypoxemic respiratory failure: exploratory findings in a single-center retrospective cohort study. Acad Emerg Med. 2020;27:1249–1259. - PubMed