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Observational Study
. 2022 Feb 17:13:801133.
doi: 10.3389/fendo.2022.801133. eCollection 2022.

Evaluation of Muscle Mass and Stiffness with Limb Ultrasound in COVID-19 Survivors

Sarah Damanti  1 , Marta Cilla  1 , Bruno Tuscano  2 , Rebecca De Lorenzo  3 , Giuseppina Manganaro  3 , Aurora Merolla  3 , Giacomo Pacioni  3 , Chiara Pomaranzi  3 , Valeria Tiraferri  3 , Sabina Martinenghi  4 , Giordano Vitali  4 , Emanuele Bosi  3   4 , Caterina Conte  5   6 , Andrea Giustina  7 , Moreno Tresoldi  1 , Patrizia Rovere Querini  2   8
Affiliations
Observational Study

Evaluation of Muscle Mass and Stiffness with Limb Ultrasound in COVID-19 Survivors

Sarah Damanti et al. Front Endocrinol (Lausanne). .

Abstract

Background: acute illnesses, like COVID-19, can act as a catabolic stimulus on muscles. So far, no study has evaluated muscle mass and quality through limb ultrasound in post-COVID-19 patients.

Methods: cross sectional observational study, including patients seen one month after hospital discharge for SARS-CoV-2 pneumonia. The patients underwent a multidimensional evaluation. Moreover, we performed dominant medial gastrocnemius ultrasound (US) to characterize their muscle mass and quality.

Results: two hundred fifty-nine individuals (median age 67, 59.8% males) were included in the study. COVID-19 survivors with reduced muscle strength had a lower muscle US thickness (1.6 versus 1.73 cm, p =0.02) and a higher muscle stiffness (87 versus 76.3, p = 0.004) compared to patients with normal muscle strength. Also, patients with reduced Short Physical Performance Battery (SPPB) scores had a lower muscle US thickness (1.3 versus 1.71 cm, p = 0.01) and a higher muscle stiffness (104.9 versus 81.07, p = 0.04) compared to individuals with normal SPPB scores. The finding of increased muscle stiffness was also confirmed in patients with a pathological value (≥ 4) at the sarcopenia screening tool SARC-F (103.0 versus 79.55, p < 0.001). Muscle stiffness emerged as a significant predictor of probable sarcopenia (adjusted OR 1.02, 95% C.I. 1.002 - 1.04, p = 0.03). The optimal ultrasound cut-offs for probable sarcopenia were 1.51 cm for muscle thickness (p= 0.017) and 73.95 for muscle stiffness (p = 0.004).

Discussion: we described muscle ultrasound characteristics in post COVID-19 patients. Muscle ultrasound could be an innovative tool to assess muscle mass and quality in this population. Our preliminary findings need to be confirmed by future studies comparing muscle ultrasound with already validated techniques for measuring muscle mass and quality.

Keywords: COVID - 19; muscle; muscle mass; muscle quality; sarcopenia; ultrasound.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Number of people with a pathologic value of a sarcopenia screening tool, hand grip strength and muscle performance test. SARC-F, Screening tool for sarcopenia; SPPB, Short Physical Performance Battery.
Figure 2
Figure 2
Comparison of the limb ultrasound images of a patient with (A) and without probable sarcopenia (B). (A) Muscle thickness: 1.54 cm, muscle stiffness 127 (B) Muscle thickness: 1.81 cm, muscle stiffness 46.8. RED DOTTED ARROW: muscle thickness; ORANGE ARROW: muscle deep aponeurosis; BLU CIRCLE LINE: pennation angle; GREEN line: muscle fascicle length.
See this image and copyright information in PMC

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