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Review
. 2022 Feb 18:13:853290.
doi: 10.3389/fendo.2022.853290. eCollection 2022.

Diagnosis of GH Deficiency Without GH Stimulation Tests

Anastasia Ibba  1 , Sandro Loche  1
Affiliations
Review

Diagnosis of GH Deficiency Without GH Stimulation Tests

Anastasia Ibba et al. Front Endocrinol (Lausanne). .

Abstract

Growth hormone deficiency (GHD) is the most commonly affected pituitary hormone in childhood with a prevalence of 1 in 4000-10000 live births. GH stimulation testing (GHST) is commonly used in the diagnostic workup of GHD. However, GHD can be diagnosed in some clinical conditions without the need of GHST. The diagnosis of GHD in newborns does not require stimulation testing. Likewise infants/children with delayed growth and/or short stature associated with neuroradiological abnormalities and one or more additional pituitary hormone deficiencies may not need GHST. This review summarizes the current evidence on the diagnosis of GHD without stimulation tests.

Keywords: IGF-1; children; growth; growth hormone; growth hormone stimulation tests; newborn.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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