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. 2022 Feb 24:2022:9317425.
doi: 10.1155/2022/9317425. eCollection 2022.

Blood Acylated Ghrelin Concentrations in Healthy Term Newborns: A Prospective Cohort Study

Neha Parveen  1 , Ayesha Ahmad  1 , Syed Manazir Ali  1 , Shagufta Moin  2 , Nasreen Noor  3
Affiliations

Blood Acylated Ghrelin Concentrations in Healthy Term Newborns: A Prospective Cohort Study

Neha Parveen et al. Int J Pediatr. .

Abstract

Objective: The effect of ghrelin, a growth hormone (GH) secretagogue on growth of neonates, has been studied in the past, but not fully clarified. We aimed to investigate the relationship between ghrelin and growth parameters at birth and at the age of three months in healthy term infants. Methodology. This was a prospective observational study carried out in a tertiary care hospital. Eighty-four infants born at gestational ages between 37 and 42 weeks and classified as term small for gestational age (SGA) and appropriate for gestational age (AGA) were included in the study. Estimation of acylated ghrelin (AG) concentrations was done in the cord blood at birth and in venous blood at the age of 3 months in all the infants. The correlation between AG concentrations and growth parameters at birth and at 3 months was studied.

Results: AG concentrations were significantly higher in SGA (236.16 ± 152.4 pg/ml) than AGA neonates (59.45 ± 20.95 pg/ml) at birth. Concentrations were observed to be negatively correlated with birth weight (r = -0.34, p value 0.03), birth length, and head circumference (r = -0.509 and -0.376, respectively) in SGA neonates. However, at 3 months, AG concentrations did not correlate with changes in anthropometric parameters in both the groups.

Conclusion: Cord acylated ghrelin concentrations are higher in SGA neonates, and the concentrations are inversely proportional to the birth weight. Hence, its role as a surrogate marker for intrauterine nutrition can be suggested. However, its concentrations do not correlate with anthropometric parameters in early postnatal growth, suggesting it may not have a direct role in postnatal growth.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Flow chart of patients in the study.
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References

    1. Cho W. K., Suh B. K. Catch-up growth and catch-up fat in children born small for gestational age. Korean Journal of Pediatrics . 2016;59(1):1–7. doi: 10.3345/kjp.2016.59.1.1. - DOI - PMC - PubMed
    1. Lee A. C., Kozuki N., Cousens S., et al. Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets. BMJ . 2017;358 - PMC - PubMed
    1. Campisi S. C., Carbone S. E., Zlotkin S. Catch-up growth in full-term small for gestational age infants: a systematic review. Advances in Nutrition . 2019;10(1):104–111. doi: 10.1093/advances/nmy091. - DOI - PMC - PubMed
    1. Kesavan K., Devaskar S. U. Intrauterine growth restriction: postnatal monitoring and outcomes. Pediatric Clinics of North America . 2019;66(2):403–423. doi: 10.1016/j.pcl.2018.12.009. - DOI - PubMed
    1. Imdad A., Bhutta Z. A. Maternal nutrition and birth outcomes: effect of balanced protein-energy supplementation. Paediatric and Perinatal Epidemiology . 2012;26:178–190. doi: 10.1111/j.1365-3016.2012.01308.x. - DOI - PubMed

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