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Case Reports
. 2022 Jan 30;14(1):e21738.
doi: 10.7759/cureus.21738. eCollection 2022 Jan.

Peritumoral Immunoglobulin M Lambda Light Chain Amyloidosis in a Patient With Advanced Follicular Lymphoma

Kalpesh Shah  1 , Sudarsan V Kollimuttathuillam  2 , Nyan Bethel  1 , Hamid Shaaban  3
Affiliations
Case Reports

Peritumoral Immunoglobulin M Lambda Light Chain Amyloidosis in a Patient With Advanced Follicular Lymphoma

Kalpesh Shah et al. Cureus. .

Abstract

Peritumoral light chain (AL) amyloidosis secondary to lymphoid malignancies is a rare but well-described entity. Peritumoral deposition of amyloid without systemic amyloidosis has been described in mucosa-associated lymphoid tissue (MALT) lymphomas; however, there are no reported cases of follicular lymphoma with localized peritumoral AL amyloidosis without systemic involvement of amyloidosis. We present a rare case of a patient with advanced follicular lymphoma with peritumoral lymph node IgM lambda light chain amyloidosis without an underlying monoclonal gammopathy or plasma cell dyscrasia.

Keywords: amyloidosis; follicular; light chain; lymphoma; peritumoral.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. A (left) reveals H&E staining for centroblasts and centrocytes, and B (right) reveals H&E staining revealing amyloid
Figure 2
Figure 2. A (left) reveals positive staining for CD20, and B (right) reveals positive staining for BCL2
Figure 3
Figure 3. A (left) reveals positive staining for Congo red stain, and B (right) reveals positive staining for BCL6
See this image and copyright information in PMC

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