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. 2022 Feb 16:12:849951.
doi: 10.3389/fonc.2022.849951. eCollection 2022.

Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study

Birgit D A Lavrijssen  1   2 , Rikje Ruiter  2   3 , Jesse Fest  1   4 , Mohammad A Ikram  2 , Bruno H Stricker  2 , Casper H J van Eijck  1
Affiliations

Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study

Birgit D A Lavrijssen et al. Front Oncol. .

Abstract

Background: This study aims to assess trends in patient-related factors and treatment strategies in Dutch colorectal cancer (CRC) patients and their effect on survival.

Methods: Data were obtained from the Rotterdam study, an ongoing population-based study of individuals aged ≥45 years. Between 1990 and 2014, incident, pathology-confirmed CRC cases were divided into two groups based on date of diagnosis (either before or after January 1, 2003). Patient characteristics, initial treatment, and date of mortality were collected. Analyses were performed using Kaplan-Meier and Cox proportional hazard models.

Results: Of 14,928 individuals, 272 developed colon cancer and 124 rectal cancer. Median follow-up was 13.2 years. Patients diagnosed after January 1, 2003 were treated chemotherapeutically more often than those diagnosed prior to this date in colon cancer (28.6% vs. 9.1%, p = 0.02) and treated more often with chemotherapy (38.6% vs. 12.3%, p = 0.02) and radiotherapy (41.3% vs. 10.2%, p = 0.001) in rectal cancer. Overall survival, adjusted for patient, tumor characteristics, and treatment, improved in rectal cancer (HR, 0.31; 95% CI, 0.13-0.74) but remained stable in colon cancer (HR, 1.28; 95% CI, 0.84-1.95).

Conclusion: Chemotherapeutic agents and radiotherapy are increasingly used in CRC patients. Survival in rectal cancer improved, whereas in colon cancer this was not observed.

Keywords: colorectal cancer; survival; treatment; trends; tumor staging.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Kaplan-Meier estimate of survival in colon cancer patients and rectal cancer patients. (A) The 5-year overall survival, in months, after diagnosis for patients of all tumor stages combined in colon cancer patients. The curves are compared using the Log-Rank test. (B) The 5-year overall survival, displayed in months, after diagnosis for patients of all tumor stages combined in rectal cancer patients. The curves are compared using the Log-Rank test.
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