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Review
. 2022 Feb 16:9:841223.
doi: 10.3389/fmolb.2022.841223. eCollection 2022.

Gut Microbiome and the Role of Metabolites in the Study of Graves' Disease

Haihua Liu  1   2 , Huiying Liu  1   2 , Chang Liu  1   2 , Mengxue Shang  1   2 , Tianfu Wei  1   2 , Peiyuan Yin  1
Affiliations
Review

Gut Microbiome and the Role of Metabolites in the Study of Graves' Disease

Haihua Liu et al. Front Mol Biosci. .

Abstract

Graves' disease (GD) is an autoimmune thyroid disease (AITD), which is one of the most common organ-specific autoimmune disorders with an increasing prevalence worldwide. But the etiology of GD is still unclear. A growing number of studies show correlations between gut microbiota and GD. The dysbiosis of gut microbiota may be the reason for the development of GD by modulating the immune system. Metabolites act as mediators or modulators between gut microbiota and thyroid. The purpose of this review is to summarize the correlations between gut microbiota, microbial metabolites and GD. Challenges in the future study are also discussed. The combination of microbiome and metabolome may provide new insight for the study and put forward the diagnosis, treatment, prevention of GD in the future.

Keywords: autoimmunity; graves’ disease (GD); gut microbiome; metabol(n)omics; metabolites.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Association between gut microbiota, metabolites, and thyroid autoimmune diseases.
See this image and copyright information in PMC

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