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Review
. 2022 Jun;24(6):703-714.
doi: 10.1007/s11912-022-01217-z. Epub 2022 Mar 7.

Neuroendocrine Tumors: a Relevant Clinical Update

Emma N Rizen  1 , Alexandria T Phan  2   3
Affiliations
Review

Neuroendocrine Tumors: a Relevant Clinical Update

Emma N Rizen et al. Curr Oncol Rep. 2022 Jun.

Abstract

Purpose of review: The field of neuroendocrine oncology has changed much since the time of Oberndorfer first described and coined the term carcinoid. The purpose of this review is to summarize recent findings and highlight clinically relevant updates in the management of NENs, particularly those that are practice changing.

Recent findings: Neuroendocrine tumors (NETs) have replaced carcinoid tumor, for the most part. The classification of neuroendocrine neoplasms (NENs) improved, and the epidemiological understanding of this disease group also expanded with global collaborations and maturation of large tumor registries. Clarity in the utility of some NET biomarkers continues to be evolving. Knowledge of molecular drivers of tumorigenesis increases, and scientific/technological advancements lead the way to multiple drug approvals for the treatment of advanced NETs. The incidence and prevalence of NENs continue to increase, and patients are living longer. Better understanding of molecular drivers and further understanding of the role of immunotherapy in NENs will further elevate the level of care and transform care for all patients with NENs.

Keywords: Carcinoid tumor; Classification; Epidemiology; Neuroendocrine tumor; Review; Treatment options.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance
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