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. 2022 Apr;35(3):779-782.
doi: 10.1007/s40620-022-01275-3. Epub 2022 Mar 7.

Acute interstitial nephritis after vaccination with BNT162b2

Sonja Rieckmann  1 , Felix S Seibert  1 , Maximilian Hogeweg  1 , Sebastian Bertram  1 , Adrian A N Doevelaar  1 , Kerstin Amann  2 , Nina Babel  1 , Timm H Westhoff  3
Affiliations

Acute interstitial nephritis after vaccination with BNT162b2

Sonja Rieckmann et al. J Nephrol. 2022 Apr.
No abstract available

Keywords: BNT162b2; COVID-19; Interstitial nephritis; Kidney injury; Vaccination.

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Conflict of interest statement

The authors have declared no conflicts of interest.

Figures

Fig. 1
Fig. 1
Kidney biopsy of patient 1 in PAS staining showing (A, × 20) acute tubular necrosis (arrow), interstitial edema and lymphoplasmacellular interstitial infiltration with few eosinophil granulocytes in HE staining (B, × 40, arrow), consistent with acute interstitial nephritis. Kidney biopsy of patient 2 in PAS staining showing (C, × 20) dense lymphoplasmacellular infiltration (arrow) with eosinophil granulocytes and diffuse acute tubular necrosis consistent with acute interstitial nephritis as well as a normal glomerulus. Immunohistochemistry (D, × 40) revealed mild granular mesangial IgA deposition (arrow) in an otherwise normal glomerulus. Kidney biopsy of patient 3 in PAS staining showing (E, × 20) severe, locally destructive interstitial nephritis with prominent diffuse acute tubular necrosis (arrow) and slight eosinophilia in HE staining (F, × 40, arrow)
See this image and copyright information in PMC

References

    1. Mevorach D, Anis E, Cedar N, et al. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. N Engl J Med. 2021;385:2140–2149. doi: 10.1056/NEJMoa2109730. - DOI - PMC - PubMed
    1. Praga M, Gonzalez E. Acute interstitial nephritis. Kidney Int. 2010;77:956–961. doi: 10.1038/ki.2010.89. - DOI - PubMed
    1. Tiffany N, Caza CAC, Messias N, Hannoudi A, et al. Glomerular disease in temporal association to SARS-CoV-2 vaccination—a series of 29 cases. Kidney360. 2021;2:1770–1780. doi: 10.34067/KID.0005372021. - DOI - PMC - PubMed
    1. Leclerc S, Royal V, Lamarche C, et al. Minimal change disease with severe acute kidney injury following the Oxford-AstraZeneca COVID-19 vaccine: a case report. Am J Kidney Dis. 2021;78:607–610. doi: 10.1053/j.ajkd.2021.06.008. - DOI - PMC - PubMed
    1. Abramson M, Mon-Wei YuS, Campbell KN, et al. IgA nephropathy after SARS-CoV-2 vaccination. Kidney Med. 2021;3:860–863. doi: 10.1016/j.xkme.2021.05.002. - DOI - PMC - PubMed

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