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Observational Study
. 2022 Jul;28(7):1257-1261.
doi: 10.1002/lt.26452. Epub 2022 Apr 28.

Sinusoidal obstruction syndrome after liver transplantation: A multicenter observational study

Aránzazu Caballero-Marcos  1   2 , Isabel Peligros  3 , Judith Pérez-Rojas  4 , Isabel Campos-Varela  2   5 , Jordi Colmenero  2   6 , Miguel Ángel Gómez-Bravo  7 , Iago Justo  8 , Alejandra Otero  9 , Esther Molina-Pérez  10 , Luisa González-Diéguez  11 , Carme Baliellas  12 , Mario Romero-Cristobal  1   2 , Victoria Aguilera  13 , Lluís Castells  2   5 , Alba Díaz  2   14 , Luis Miguel Marín-Gómez  7 , Carmelo Loinaz  8 , Rafael Bañares  1   2 , Magdalena Salcedo  1   2
Affiliations
Observational Study

Sinusoidal obstruction syndrome after liver transplantation: A multicenter observational study

Aránzazu Caballero-Marcos et al. Liver Transpl. 2022 Jul.
No abstract available

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Conflict of interest statement

Jordi Colmenero consults for and is on the speakers' bureau for Chiesi. He is on the speakers' bureau for Astellas. The other authors do not have any conflicts.

Figures

FIGURE 1
FIGURE 1
(A) Sinusoidal dilatation around central vein (zone 3). (B) Perisinusoidal hemorrhage and sinusoidal dilatation. (C) Centrilobular vein fibrosis (hematoxylin‐eosin and Masson’s stain), obliterative fibrous lesion. (D) Centrilobular vein fibrosis, evolved obliterative lesion. (E) Peliosis hepatis. Irregular blood‐filled cavities with no endothelial lining (hematoxylin‐eosin). (F) Nodular regenerative hyperplasia (hematoxylin‐eosin and reticulin stain). The nodularity results from zones of atrophic hepatocytes alternating with areas of normal‐sized hepatocytes
FIGURE 2
FIGURE 2
Clinical presentation of SOS. (A) Interval between LT and SOS onset according to the presence of ascites. Bars represent mean time from liver transplantation to SOS in months. Error bars indicate the 95% confidence interval. (B) AP and GGT levels according to the interval between LT and SOS. Bars represent mean levels of AP and GGT. Error bars indicate the 95% confidence interval. (C) Comparison of HVPG according to the need of retransplantation. The box ranges from Q1 (the first quartile) to Q3 (the third quartile) of the distribution and the range represent the IQR. The median is indicated by a line across the box. The whiskers on box plots extend from Q1 and Q3 to the most extreme data points. (D) Cumulative incidence of retransplantation in the presence of competing risks in patients with SOS according to the type of treatment. Retransplantation as the event of interest and death as the competing event. (*p < 0.005)
See this image and copyright information in PMC

References

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