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. 2022 May;38(4):319-325.
doi: 10.1089/jop.2021.0095. Epub 2022 Mar 7.

Novel Combined Lidocaine/Povidone Iodine Delivery System for Preintravitreal Injection

Parissa Ziaei  1 , Jayde L Resnick  1 , Nicholas Stella  1 , Morgan V DiLeo  1   2   3   4   5
Affiliations

Novel Combined Lidocaine/Povidone Iodine Delivery System for Preintravitreal Injection

Parissa Ziaei et al. J Ocul Pharmacol Ther. 2022 May.

Abstract

Purpose: Intravitreal injection has become a popular treatment for various retina disorders and dramatically increased over the past few years. In traditional preintravitreal injection, the preparation steps are time consuming for practitioners who perform a significant number of injections per day. Besides, lidocaine gel (L-Gel) shows a potential absorption barrier on the antibacterial effect of povidone iodine (PI). Methods: In this study, we describe a L/PI gel system as an alternative approach to address these issues for traditional preinjection drug administration. Lidocaine and PI are loaded in a thermoresponsive gel instilled as a liquid to the lower fornix that transitions to a stable, solid gel depot. Results and Conclusion: The gel demonstrated decrease in conjunctival touch sensitivity and sufficient bacteria killing with a single step, suggesting a significant decrease in the time required and less potential for drug inhibition due to sequential administration.

Keywords: conjunctival touch sensitivity; intravitreal injection; lidocaine; povidone iodine.

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Conflict of interest statement

No competing financial interests exist.

Figures

FIG. 1.
FIG. 1.
Lidocaine and PI release kinetics from L/PI-ge1. (A) PI release result, (B) Lidocaine release result (n = 3). Error bars represent the mean ± standard deviation. PI, povidone iodine. Color images are available online.
FIG. 2.
FIG. 2.
Evaluation of the antiseptic effect of L/PI-gel. In samples (A–E, G), the S. epidermidis bacteria covered with E-Gel, Akten® Gel, L-Gel, 5% PI solution, PI-Gel, and L/PI-Gel, respectively. (F) Akten Gel was covered for 1 min then 5% PI solution was placed. PI-Gel, povidone iodine gel; L-Gel, lidocaine gel. Color images are available online.
FIG. 3.
FIG. 3.
Compare different CTT measurements. Evaluate anesthetic effect of L/PI-Gels compare with different control conditions. CTT, conjunctival touch threshold. Color images are available online.
See this image and copyright information in PMC

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