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. 2022 Feb;37(1):175-179.
doi: 10.3803/EnM.2021.1262. Epub 2022 Feb 28.

Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes

Liisa Saare  1 , Aleksandr Peet  1   2 , Vallo Tillmann  1   2
Affiliations

Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes

Liisa Saare et al. Endocrinol Metab (Seoul). 2022 Feb.

Abstract

The incidence of type 1 diabetes (T1D) is increasing throughout the world. This trend may be explained by the accelerator hypothesis. Our study investigated growth, its biochemical markers, and their associations with the development of diabetes-associated autoantibodies (DAAB) in 219 children with genetic risk for T1D. Subjects were divided into risk groups based on their human leukocyte antigen genotype. Children in the moderate- to high-risk group were significantly taller when corrected to mid-parental height and had a lower insulin-like growth factor 1 (IGF-1)/IGF-1 binding protein (IGFBP-3) molar ratio than those in the low-risk group (corrected height standard deviation score 0.22±0.93 vs. -0.04±0.84, P<0.05; molar ratio 0.199±0.035 vs. 0.211+0.039, P<0.05). Children with DAAB tended to be taller and to have a higher body mass index than those with no DAAB. Our results suggest that the accelerator hypothesis explaining the increasing incidence of T1D may not solely be dependent on environmental factors, but could be partially genetically determined.

Keywords: Body height; Body mass index; Body weight; Diabetes mellitus, type 1; HLA antigens.

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Conflict of interest statement

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

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