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Review
. 1986 Jun 20:379:3-26.
doi: 10.1016/s0378-4347(00)80680-5.

Advanced instrumentation and strategies for metabolic profiling

J F Holland, J J Leary, C C Sweeley
Review

Advanced instrumentation and strategies for metabolic profiling

J F Holland et al. J Chromatogr. .

Abstract

This review summarizes the instrumental techniques applicable for metabolic profiling analysis. Since its origin with the work of Roger Williams, use has been made of planar chromatography, column liquid chromatography, electrophoresis, gas-liquid chromatography, and mass spectrometry to obtain analyte patterns. Strategies for the analysis of various metabolites including organic acids, steroids, drugs, bile acids, carbohydrates, and proteins are discussed.

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