Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Mar 1;50(2):48-57.
doi: 10.15586/aei.v50i2.539. eCollection 2022.

Desensitization to drugs in children

Luis Felipe Ensina  1 , Mara Morelo Rocha Felix  2 , Fernanda Sales da Cunha  2 , Jean-Christoph Caubet  3
Affiliations
Review

Desensitization to drugs in children

Luis Felipe Ensina et al. Allergol Immunopathol (Madr). .

Abstract

Better knowledge and understanding about drug desensitization is required in the pediatric population, since there is little literature available about it and the most pediatric desensitization protocols have been adapted from adult instructions.Aiming to soften this issue and foster the future studies, this article presents a recent review about mechanisms of desensitization, diagnostic tools, and up to date management of drug hypersensitivity reactions in children. Bringing up an overview of pediatric hypersensitivity reactions to chemotherapy, biologic agents, antibiotics, nonsteroidal anti-inflammatory drugs, and vaccines.

Keywords: adolescent; children; desensitization; drug allergy; drug hypersensitivity; pediatric.

PubMed Disclaimer

References

    1. 1. Muraro A, Lemanske RF Jr, Castells M, Torres MJ, Khan D, Simon HU, et al. Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis—PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology. Allergy. 2017;72(7):1006–21. 10.1111/all.13132 - DOI
    1. 2. Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, et al. International consensus on drug allergy. Allergy. 2014;69(4):420–37. 10.1111/all.12350 - DOI
    1. 3. Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med. 2003;139(8):683–93. 10.7326/0003-4819-139-8-200310210-00012 - DOI
    1. 4. de Las Vecillas Sánchez L, Alenazy LA, Garcia-Neuer M, Castells MC. Drug hypersensitivity and desensitizations: Mechanisms and new approaches. Int J Mol Sci. 2017;18(6):1316. 10.3390/ijms18061316 - DOI
    1. 5. Picard M, Pur L, Caiado J, Giavina-Bianchi P, Galvão VR, Berlin ST, et al. Risk stratification and skin testing to guide re-exposure in taxane-induced hypersensitivity reactions. J Allergy Clin Immunol. 2016;137(4):1154–64.e12. 10.1016/j.jaci.2015.10.039 - DOI

MeSH terms

Substances

LinkOut - more resources