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. 2022 Mar 8;22(1):110.
doi: 10.1186/s12886-022-02331-z.

Subthreshold micropulse laser photocoagulation versus half-dose photodynamic therapy for acute central serous chorioretinopathy

Miao Zeng  1 , Xiao Chen  1 , Yanping Song  1 , Chunyan Cai  2
Affiliations

Subthreshold micropulse laser photocoagulation versus half-dose photodynamic therapy for acute central serous chorioretinopathy

Miao Zeng et al. BMC Ophthalmol. .

Abstract

Purpose: To compare the efficacy and safety of subthreshold micropulse (STMP) laser photocoagulation and half-dose photodynamic therapy (PDT) in the treatment of acute central serous chorioretinopathy (CSC).

Methods: A total of 39 acute CSC patients were included. 18 patients were treated with STMP laser and 21 patients were treated with half-dose PDT. The main outcome measures were best-corrected visual acuity (BCVA) according to Early Treatment Diabetic Retinopathy Study (ETDRS) chart, the proportion of eyes with complete resolution of subretinal fluid, the number of treatments, and the retinal sensitivity by microperimetry during the 12-month study period.

Results: The mean number of treatments during the 12-month period was 1.6 in STMP group and 1.3 in half-dose PDT group, respectively (P = 0.174). The proportion of eyes with complete resolution of subretinal fluid was 83.3% in STMP group compared with 90.5% in half-dose PDT group at 12-month (P = 0.647). The mean BCVA at 12-month after treatment was 75.28 ± 12.58 for STMP group and 76.62 ± 11.57 for half-dose PDT group, respectively (P = 0.731). No statistically significant difference was found in the mean retinal sensitivity between the two groups during the 12 months follow-up (P = 0.701 at 3 months; P = 0.725 at 6 months; P = 0.695 at 12 months).

Conclusions: Subthreshold micropulse Laser Photocoagulation is as effective as half-dose PDT for acute CSC, while minimizing the damage effect on retinal.

Keywords: Central serous chorioretinopathy; Laser photocoagulation; Photodynamic therapy; Subthreshold micropulse.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Graph showing the serial changes in mean Early Treatment Diabetic Retinopathy Study(ETDRS) best-corrected visual acuity(BCVA) of patients in the STMP group (dashed line) and in the half-dose PDT group (solid line)
Fig. 2
Fig. 2
Graph showing the serial changes in mean central foveal thickness (CFT) of patients in the STMP group (dashed line) and in the half-dose PDT group (solid line)
Fig. 3
Fig. 3
Graph showing the serial changes in mean central retinal sensitivity of patients in the STMP group (dashed line) and in the half-dose PDT group (solid line)
See this image and copyright information in PMC

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