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. 2022 Mar 9;20(1):113.
doi: 10.1186/s12916-022-02242-2.

Differential health impact of intervention programs for time-varying disease risk: a measles vaccination modeling study

Allison Portnoy  1 , Yuli Lily Hsieh  2 , Kaja Abbas  3 , Petra Klepac  3 , Heather Santos  4 , Logan Brenzel  5 , Mark Jit #  3 , Matthew Ferrari #  4
Affiliations

Differential health impact of intervention programs for time-varying disease risk: a measles vaccination modeling study

Allison Portnoy et al. BMC Med. .

Abstract

Background: Dynamic modeling is commonly used to evaluate direct and indirect effects of interventions on infectious disease incidence. The risk of secondary outcomes (e.g., death) attributable to infection may depend on the underlying disease incidence targeted by the intervention. Consequently, the impact of interventions (e.g., the difference in vaccination and no-vaccination scenarios) on secondary outcomes may not be proportional to the reduction in disease incidence. Here, we illustrate the estimation of the impact of vaccination on measles mortality, where case fatality ratios (CFRs) are a function of dynamically changing measles incidence.

Methods: We used a previously published model of measles CFR that depends on incidence and vaccine coverage to illustrate the effects of (1) assuming higher CFR in "no-vaccination" scenarios, (2) time-varying CFRs over the past, and (3) time-varying CFRs in future projections on measles impact estimation. We used modeled CFRs in alternative scenarios to estimate measles deaths from 2000 to 2030 in 112 low- and middle-income countries using two models of measles transmission: Pennsylvania State University (PSU) and DynaMICE. We evaluated how different assumptions on future vaccine coverage, measles incidence, and CFR levels in "no-vaccination" scenarios affect the estimation of future deaths averted by measles vaccination.

Results: Across 2000-2030, when CFRs are separately estimated for the "no-vaccination" scenario, the measles deaths averted estimated by PSU increased from 85.8% with constant CFRs to 86.8% with CFRs varying 2000-2018 and then held constant or 85.9% with CFRs varying across the entire time period and by DynaMICE changed from 92.0 to 92.4% or 91.9% in the same scenarios, respectively. By aligning both the "vaccination" and "no-vaccination" scenarios with time-variant measles CFR estimates, as opposed to assuming constant CFRs, the number of deaths averted in the vaccination scenarios was larger in historical years and lower in future years.

Conclusions: To assess the consequences of health interventions, impact estimates should consider the effect of "no-intervention" scenario assumptions on model parameters, such as measles CFR, in order to project estimated impact for alternative scenarios according to intervention strategies and investment decisions.

Keywords: Health impact modeling; Measles; Time-dependent risk; Vaccination.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Measles deaths by analytic scenario for 112 countries across 2000 to 2030, assuming a constant case fatality ratio in “no-vaccination” scenario for Pennsylvania State University (PSU) model and DynaMICE model. Note: The top line of each shaded area shows estimated measles deaths in the “no-vaccination” scenario, and the bottom line shows estimated measles deaths in the “vaccination” scenario. The shaded region represents the amount of measles deaths averted by vaccination
Fig. 2
Fig. 2
Measles deaths by analytic scenario for 112 countries across 2000 to 2030, assuming a time-varying case fatality ratio in “no-vaccination” scenario for Pennsylvania State University (PSU) model and DynaMICE model. Note: The top line of each shaded area shows estimated measles deaths in the “no-vaccination” scenario, and the bottom line shows estimated measles deaths in the “vaccination” scenario. The shaded region represents the amount of measles deaths averted by vaccination
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