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Comment
. 2022 Apr;43(4):277-279.
doi: 10.1016/j.it.2022.02.004. Epub 2022 Mar 5.

Magnesium for T cells: strong to the finish!

Santosha Vardhana  1 , Michael L Dustin  2
Affiliations
Comment

Magnesium for T cells: strong to the finish!

Santosha Vardhana et al. Trends Immunol. 2022 Apr.

Abstract

'Popeye, the Sailor' cartoons taught children that eating spinach boosts strength and helps defend against bullies. Lötscher and colleagues report that dietary deficiency of magnesium ions (Mg2+), against which eating spinach is an excellent antidote, impairs the activity of a key adhesion molecule, LFA-1, and hinders the ability of CD8+ T cells to grapple with assorted bullies, such as tumors and bacteria.

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Conflict of interest statement

Declaration of interests None declared by authors.

Comment on

  • Magnesium sensing via LFA-1 regulates CD8+ T cell effector function.
    Lötscher J, Martí I Líndez AA, Kirchhammer N, Cribioli E, Giordano Attianese GMP, Trefny MP, Lenz M, Rothschild SI, Strati P, Künzli M, Lotter C, Schenk SH, Dehio P, Löliger J, Litzler L, Schreiner D, Koch V, Page N, Lee D, Grählert J, Kuzmin D, Burgener AV, Merkler D, Pless M, Balmer ML, Reith W, Huwyler J, Irving M, King CG, Zippelius A, Hess C. Lötscher J, et al. Cell. 2022 Feb 17;185(4):585-602.e29. doi: 10.1016/j.cell.2021.12.039. Epub 2022 Jan 19. Cell. 2022. PMID: 35051368

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