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. 2022 Mar 1;135(5):jcs259501.
doi: 10.1242/jcs.259501. Epub 2022 Mar 9.

Perilipins at a glance

Charles P Najt  1 , Mahima Devarajan  1 , Douglas G Mashek  1   2
Affiliations

Perilipins at a glance

Charles P Najt et al. J Cell Sci. .

Abstract

Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy metabolism, membrane synthesis and production of lipid-derived signaling molecules. While compositional differences in the phospholipid monolayer or neutral lipid core of LDs impact their metabolism and function, the proteome of LDs has emerged as a major influencer in all aspects of LD biology. The perilipins (PLINs) are the most studied and abundant proteins residing on the LD surface. This Cell Science at a Glance and the accompanying poster summarize our current knowledge of the common and unique features of the mammalian PLIN family of proteins, the mechanisms through which they affect cell metabolism and signaling, and their links to disease.

Keywords: Lipid droplets; Lipid metabolism; Lipid signaling; Perilipins.

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Conflict of interest statement

Competing interests The authors declare no competing or financial interests.

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