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Case Reports
. 2021 Nov 15;35(2):245-247.
doi: 10.1080/08998280.2021.2001260. eCollection 2022.

Esthesioneuroblastoma presenting with orbital signs and ectopic adrenocorticotropic hormone syndrome

Wesley M Gillette  1 , Donald Carroll Hubbard  2 , Jana Nicole Waters  1 , Adam Stephen Johnson  3
Affiliations
Case Reports

Esthesioneuroblastoma presenting with orbital signs and ectopic adrenocorticotropic hormone syndrome

Wesley M Gillette et al. Proc (Bayl Univ Med Cent). .

Abstract

A 23-year-old woman with known nasal polyps and a recent seizure presented with diplopia, proptosis, extraocular motility deficits, and stigmata of Cushing syndrome. Computed tomography showed a left sinonasal mass extending into the left orbit. Laboratory evaluation revealed refractory hypokalemia and significantly elevated adrenocorticotropic hormone. Histopathologic exam confirmed the diagnosis of esthesioneuroblastoma.

Keywords: Esthesioneuroblastoma; neuroesthesioma; olfactory neuroblastoma; sinonasal tumor.

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Figures

Figure 1.
Figure 1.
(a) CT of the head demonstrating a 6.4 cm sinonasal mass eroding into the inferonasal left orbit with displacement of the medial rectus muscle. (b) T1-weighted MRI of the face demonstrating involvement of the maxillary and ethmoid sinuses with extension through the orbit to the left anterior cranial fossa floor.
Figure 2.
Figure 2.
Histopathology with hematoxylin and eosin stain of nasal biopsy specimen under (a) low magnification, (b) medium magnification, (c) high magnification, and (d) low magnification with synaptophysin immunohistochemical staining. There are nests of small, round, blue cells with somewhat foamy cytoplasm admixed within granulation tissue.
See this image and copyright information in PMC

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