Research progress on RNA-binding proteins in breast cancer

Abstract

Breast cancer is the most common malignancy among women, and the abnormal regulation of gene expression serves an important role in its occurrence and development. However, the molecular mechanisms underlying gene expression are highly complex and heterogeneous, and RNA-binding proteins (RBPs) are among the key regulatory factors. RBPs bind targets in an environment-dependent or environment-independent manner to influence mRNA stability and the translation of genes involved in the formation, progression, metastasis and treatment of breast cancer. Due to the growing interest in these regulators, the present review summarizes the most influential studies concerning RBPs associated with breast cancer to elucidate the role of RBPs in breast cancer and to assess how they interact with other key pathways to provide new molecular targets for the diagnosis and treatment of breast cancer.

Keywords: RNA-binding protein; breast cancer; research progress.

Figure 1.

eIF4E, its target genes and its modulators in cellular pathways. Arrows indicate activation.

Figure 2.

HuR, its target genes and its modulators in cellular pathways. Arrows indicate activation and blunted lines indicate inhibition.

Figure 3.

IMPs, their target genes and their modulators in cellular pathways. Arrows indicate activation and blunted lines indicate inhibition.

Figure 4.

LIN28, its target genes and its modulators in cellular pathways. Arrows indicate activation and blunted lines indicate inhibition.

Figure 5.

MSI, their target genes and their modulators in cellular pathways. Arrows indicate activation and blunted lines indicate inhibition.

Figure 6.

RBM38, its target genes and its modulators in cellular pathways. Arrows indicate activation and blunted lines indicate inhibition.

Figure 7.

SAM68, its target genes and its modulators in cellular pathways. Arrows indicate activation and blunted or crossed-out lines indicate inhibition.