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Review
. 2021 Nov 10;6(2):204-211.
doi: 10.1002/ags3.12517. eCollection 2022 Mar.

Research Progress on the Relationship Between Inflammation and Colorectal Cancer

Feng Zhang  1 , Song Qiao  1
Affiliations
Review

Research Progress on the Relationship Between Inflammation and Colorectal Cancer

Feng Zhang et al. Ann Gastroenterol Surg. .

Abstract

Colorectal cancer is one of the common malignant tumors. Relevant epidemiology and a large number of experimental studies have proved that chronic inflammation is highly correlated with the occurrence and development of colorectal cancer. And inflammatory bowel disease has been proven to be an independent risk factor for colorectal cancer. Various inflammatory cells participate in the establishment of the chronic inflammatory intestinal microenvironment required for the onset of colorectal cancer. The abnormal signal pathways mediated by various inflammatory factors and inflammatory mediators promote the occurrence of tumors, which are related to colorectal cancer and pathogenesis-related inflammation mechanisms. At the gene level, miRNAs can also affect the pathogenesis of colorectal cancer by regulating mesenchymal epithelial transformation. This article reviews the relationship between inflammation and colorectal cancer as well as the related inflammatory mechanisms.

Keywords: MiRNAs; colorectal cancer; cytokines; inflammation; intestinal microenvironment.

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