Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 1;4(3):e0651.
doi: 10.1097/CCE.0000000000000651. eCollection 2022 Mar.

Albumin Kinetics in Sepsis and COVID-19

Suhail Sarwar Siddiqui  1 , Nilanchal Chakraborty  2 , Syed Nabeel Muzaffar  1 , Mohan Gurjar  3
Affiliations

Albumin Kinetics in Sepsis and COVID-19

Suhail Sarwar Siddiqui et al. Crit Care Explor. .

Abstract

Hypoalbuminemia has been associated with poor outcome in critically ill population including sepsis and COVID-19. The observational study by Su et al showed a favorable albumin kinetics, with an initial downwards trend followed by recovery back to the predicted albumin levels, in survivors of COVID-19 and sepsis-induced acute respiratory distress syndrome (ARDS). However, nonsurvivors in COVID-19 group did not have an upwards recovery slope, while those in sepsis group did not follow any sort of albumin kinetics. Thus, authors concluded that the pattern of albumin kinetics may be predictive of outcome in COVID-19 and sepsis-induced ARDS. Here, we would like to highlight a few more points in this letter.

Keywords: COVID-19; acute respiratory distress syndrome; albumin kinetics; hypoalbuminemia; sepsis.

PubMed Disclaimer

Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

References

    1. Su C, Hoffman KL, Xu Z, et al. : Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome. Crit Care Explor 2021; 3:e0589. - PMC - PubMed
    1. Soeters PB, Wolfe RR, Shenkin A: Hypoalbuminemia: Pathogenesis and clinical significance. JPEN J Parenter Enteral Nutr 2019; 43:181–193 - PMC - PubMed
    1. Viana-Llamas MC, Arroyo-Espliguero R, Silva-Obregón JA, et al. : Hypoalbuminemia on admission in COVID-19 infection: An early predictor of mortality and adverse events. A retrospective observational study. Med Clin (Engl Ed) 2021; 156:428–436 - PMC - PubMed
    1. Norberg Å, Rooyackers O, Segersvärd R, et al. : Albumin kinetics in patients undergoing major abdominal surgery. PLoS One 2015; 10:e0136371. - PMC - PubMed
    1. Liuzzo G, Patrono C: COVID 19: In the eye of the cytokine storm. Eur Heart J 2021; 42:150–151 - PMC - PubMed