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. 2022 Jun;2(2):100067.
doi: 10.1016/j.jcvp.2022.100067. Epub 2022 Feb 19.

Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test for bronchoalveolar lavage

Tung Phan  1 , Ashley Mays  2 , Melissa McCullough  2 , Alan Wells  1
Affiliations

Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test for bronchoalveolar lavage

Tung Phan et al. J Clin Virol Plus. 2022 Jun.

Abstract

Accurate and rapid laboratory tests are essential for the prompt diagnosis of COVID-19, which is important to patients and infection control. The Xpert Xpress SARS-CoV-2 test is a real-time RT-PCR intended for the qualitative detection of nucleic acid from SARS-CoV-2 in upper respiratory specimens. In this study, we assessed the analytical performance characteristics of this rapid test for SARS-CoV-2 in 60 bronchoalveolar lavage (BAL) specimens. BAL is a specimen type that is not authorized under EUA for the Xpert Xpress SARS-CoV-2 test. The limit of detection of the Xpert Xpress SARS-CoV-2 test was 500 copies/ml. The overall agreement of the Xpert Xpress SARS-CoV-2 test was 100%. The Xpert Xpress SARS-CoV-2 test is sensitive and specific to aid in diagnosis of COVID-19 using bronchoalveolar lavage.

Keywords: BAL; COVID-19; Cepheid; Evaluation; SARS-CoV-2.

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Conflict of interest statement

The authors declare no competing financial interests.

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