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Case Reports
. 2022 Sep;187(3):419-422.
doi: 10.1111/bjd.21229. Epub 2022 May 20.

Clinical response of CARD14-associated papulosquamous eruption to an anti-interleukin-17A antibody

Benjamin Klein  1 , Regina Treudler  1 , Konstantin Dumann  1 , Andreas Boldt  2 , Isabell Schumann  3 , Jan C Simon  1 , Manfred Kunz  1
Affiliations
Case Reports

Clinical response of CARD14-associated papulosquamous eruption to an anti-interleukin-17A antibody

Benjamin Klein et al. Br J Dermatol. 2022 Sep.

Abstract

Here we present another family with CARD14-associated papulosquamous eruption, which is characterized by mutations in CARD14 and skin lesions resembling psoriasis and pityriasis rubra pilaris. We show beneficial therapeutic response to anti-IL17A treatment in one patient and performed immunomonitoring of our patient, exhibiting enhanced pSTAT3 levels in T cells before treatment, which normalized after treatment. Together, our data support the pathogenic role of IL-17A in this disease, which might have consequences for future treatment decisions in this rare condition.

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References

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