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Review
. 2022 Apr 6;13(7):848-858.
doi: 10.1021/acschemneuro.1c00775. Epub 2022 Mar 9.

Histone Deacetylases 1 and 2 in Memory Function

Ping-Chieh Pao  1   2 , Li-Huei Tsai  1   2
Affiliations
Review

Histone Deacetylases 1 and 2 in Memory Function

Ping-Chieh Pao et al. ACS Chem Neurosci. .

Abstract

Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain function through distinct mechanisms, including gene repression and DNA repair pathways. Moreover, we discuss evidence demonstrating how HDAC1 and HDAC2 could be modulated and their potential as targets to combat memory deficits.

Keywords: DNA repair; HDAC1; HDAC2; Histone acetylation; learning and memory.

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