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. 2022 Mar 9;17(3):e0264890.
doi: 10.1371/journal.pone.0264890. eCollection 2022.

Rates of respiratory syncytial virus (RSV)-associated hospitalization among adults with congestive heart failure-United States, 2015-2017

Stephanie A Kujawski  1   2 , Michael Whitaker  2   3 , Matthew D Ritchey  4   5 , Arthur L Reingold  6 , Shua J Chai  5   7   8 , Evan J Anderson  9   10   11 , Kyle P Openo  10   11   12 , Maya Monroe  13 , Patricia Ryan  13 , Erica Bye  14 , Kathryn Como-Sabetti  14 , Grant R Barney  15 , Alison Muse  15 , Nancy M Bennett  16 , Christina B Felsen  16 , Ann Thomas  17 , Courtney Crawford  17 , H Keipp Talbot  18 , William Schaffner  18 , Susan I Gerber  2 , Gayle E Langley  2 , Lindsay Kim  2   5
Affiliations

Rates of respiratory syncytial virus (RSV)-associated hospitalization among adults with congestive heart failure-United States, 2015-2017

Stephanie A Kujawski et al. PLoS One. .

Abstract

Background: Respiratory syncytial virus (RSV) can cause severe disease in adults with cardiopulmonary conditions, such as congestive heart failure (CHF). We quantified the rate of RSV-associated hospitalization in adults by CHF status using population-based surveillance in the United States.

Methods: Population-based surveillance for RSV (RSV-NET) was performed in 35 counties in seven sites during two respiratory seasons (2015-2017) from October 1-April 30. Adults (≥18 years) admitted to a hospital within the surveillance catchment area with laboratory-confirmed RSV identified by clinician-directed testing were included. Presence of underlying CHF was determined by medical chart abstraction. We calculated overall and age-stratified (<65 years and ≥65 years) RSV-associated hospitalization rates by CHF status. Estimates were adjusted for age and the under-detection of RSV. We also report rate differences (RD) and rate ratios (RR) by comparing the rates for those with and without CHF.

Results: 2042 hospitalized RSV cases with CHF status recorded were identified. Most (60.2%, n = 1230) were ≥65 years, and 28.3% (n = 577) had CHF. The adjusted RSV hospitalization rate was 26.7 (95% CI: 22.2, 31.8) per 10,000 population in adults with CHF versus 3.3 (95% CI: 3.3, 3.3) per 10,000 in adults without CHF (RR: 8.1, 95% CI: 6.8, 9.7; RD: 23.4, 95% CI: 18.9, 28.5). Adults with CHF had higher rates of RSV-associated hospitalization in both age groups (<65 years and ≥65 years). Adults ≥65 years with CHF had the highest rate (40.5 per 10,000 population, 95% CI: 35.1, 46.6).

Conclusions: Adults with CHF had 8 times the rate of RSV-associated hospitalization compared with adults without CHF. Identifying high-risk populations for RSV infection can inform future RSV vaccination policies and recommendations.

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Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: Evan Anderson reports personal fees from AbbVie, Pfizer and Sanofi Pasteur, and grants from MedImmune, Regeneron, PaxVax, Pfizer, GSK, Merck, Novavax, Sanofi Pasteur, Micron, and Janssen, outside the submitted work. He also serves on the data safety monitoring committee for Kentucky Bioscience. Stephanie Kujawski is currently an employee of Merck Sharp & Dohme Corp, a subsidiary of Merck & Co., Inc, Kenilworth, NJ, USA, and may own stock or hold stock options in the Company.

Figures

Fig 1
Fig 1. Adjusted ratesa (per 10,000 population) of RSV-associated hospitalization by congestive heart failure (CHF) status, RSV-NET, 2015–2017 (N = 2042).
aAdjusted for age and the under-detection of RSV.
See this image and copyright information in PMC

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