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Review
. 2021 Jul-Sep;62(3):835-839.
doi: 10.47162/RJME.62.3.22.

Sarcomatoid renal cell carcinoma with clear cells and eosinophilia: a case report and short review of the literature

Alexandru Neşiu  1 , Carmen Neamţu, Cristian Mircea Nicolescu, Bogdan Dan Totolici, Horia Dan Mureşanu, Mihai Cătălin Roşu, Andrei Ardelean, Vlad Constantin Silivestru, Loredana Alina Stăniş, Teodora Daniela Marţi
Affiliations
Review

Sarcomatoid renal cell carcinoma with clear cells and eosinophilia: a case report and short review of the literature

Alexandru Neşiu et al. Rom J Morphol Embryol. 2021 Jul-Sep.

Abstract

Sarcomatoid renal cell carcinoma (SRCC) is an aggressive form of de-differentiated renal cell carcinoma. We report a case of a 79-year-old male who presented himself to the Department of Emergency complaining of macroscopic hematuria for the last two days and a back pain located in the lumbar region persisting for around a month; there were no major changes in the initial laboratory tests. Abdominal ultrasonography identified a renal mass located in the lower pole of the left kidney. The computed tomography (CT) scan with iodine-based contrast revealed the left kidney had a complete deletion of corticomedullary differentiation and a large renal mass located in the lower pole with inhomogeneous iodophilia, which measured around about 15 cm in transversal diameter and 13.6 cm in craniocaudal diameter. Nephrectomy of the left kidney was performed. Histopathological and immunochemistry tests diagnosed a SRCC with clear cells and eosinophilia. We present these findings along with a short review of the literature.

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Conflict of interest statement

The authors report that they have no conflict of interests. The authors alone are responsible for the content and writing of the paper.

Figures

Figure 1
Figure 1
Histopathological aspects of sarcomatoid renal carcinoma with clear cells and eosinophilia: (A) Panoramic view of the trans-tumoral section; (B) Atypical cells with irregular nucleus shapes and featuring intense proliferation; (C and D) Atypical cells presenting lipid-rich ample cytoplasm (clear cells) and fibroblasts. Hematoxylin–Eosin (HE) staining: (A) ×40; (B) ×100; (C) ×200; (D) ×400
Figure 2
Figure 2
IHC staining for CD68, pan-CK, EMA, and vimentin (×200): slight positive IHC staining for CD68 (A), pan-CK (B), and EMA (C); intense positive IHC staining for vimentin (D). CD68: Cluster of differentiation 68; CK: Cytokeratin; EMA: Epithelial membrane antigen; IHC: Immunohistochemical
Figure 3
Figure 3
IHC staining for CK8/18, CK34βE12, S100, CK7, CK20, and HMB45 (×200): slight positive IHC staining for CK8/18 (A); negative IHC staining for CK34βE12 (B), S100 (C), CK7 (D), CK20 (E), and HMB45 (F). CK: Cytokeratin; HMB45: Human melanoma black 45; IHC: Immunohistochemical
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