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. 2022 Apr 28;139(17):2720-2724.
doi: 10.1182/blood.2021015329.

Cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after a second ChAdOx1 nCoV-19 dose

Katarzyna Krzywicka  1 , Anita van de Munckhof  1 , Julian Zimmermann  2 , Felix J Bode  2 , Giovanni Frisullo  3 , Theodoros Karapanayiotides  4 , Bernd Pötzsch  5 , Mayte Sánchez van Kammen  1 , Mirjam R Heldner  6 , Marcel Arnold  6 , Johanna A Kremer Hovinga  7 , José M Ferro  8 , Diana Aguiar de Sousa  9 , Jonathan M Coutinho  1
Affiliations

Cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after a second ChAdOx1 nCoV-19 dose

Katarzyna Krzywicka et al. Blood. .
No abstract available

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Figures

Figure 1
Figure 1
Flowchart of patient selection. Out of 202 reported patients with CVT after SARS-CoV-2 vaccination, we excluded 13, 5, and 8 cases with symptom onset outside of the 0-28 day interval, with no radiological confirmation, and duplicate and/or incomplete cases, respectively. Out of the remaining 176 cases, 124 cases developed CVT after ChAdOx1 nCoV-19 vaccination. Of these, 120 developed CVT after a first dose (61 definite, 20 probable, 10 possible, and 29 unlikely VITT), and 4 after a second dose (1 definite, 1 probable, 1 possible, and 1 unlikely).
See this image and copyright information in PMC

Comment in

  • Second-dose VITT: rare but real.
    Pavord S, Makris M. Pavord S, et al. Blood. 2022 Apr 28;139(17):2581-2583. doi: 10.1182/blood.2022016118. Blood. 2022. PMID: 35482343 Free PMC article. No abstract available.

References

    1. Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med. 2021;384(22):2092–2101. - PMC - PubMed
    1. Scully M, Singh D, Lown R, et al. Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination. N Engl J Med. 2021;384(23):2202–2211. - PMC - PubMed
    1. Schultz NH, S⊘rvoll IH, Michelsen AE, et al. Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination. N Engl J Med. 2021;384(22):2124–2130. - PMC - PubMed
    1. Sánchez van Kammen M, Aguiar de Sousa D, Poli S, et al. Cerebral Venous Sinus Thrombosis With Thrombocytopenia Syndrome Study Group Characteristics and outcomes of patients with cerebral venous sinus thrombosis in SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia. JAMA Neurol. 2021;78(11):1314–1323. - PMC - PubMed
    1. Pavord S, Scully M, Hunt BJ, et al. Clinical features of vaccine-induced immune thrombocytopenia and thrombosis. N Engl J Med. 2021;385(18):1680–1689. - PMC - PubMed

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