Plasmacytoid dendritic cells: Welcome back to the DC fold

Gary Reynolds¹, Alice Tirard², Alexandra-Chloé Villani³

Affiliations

¹ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH, UK; Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
² Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
³ Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: avillani@mgh.harvard.edu.

PMID: 35263562
DOI: 10.1016/j.immuni.2022.02.011

Free article

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Plasmacytoid dendritic cells: Welcome back to the DC fold

Gary Reynolds et al. Immunity. 2022.

Free article

. 2022 Mar 8;55(3):380-382.

doi: 10.1016/j.immuni.2022.02.011.

Authors

Gary Reynolds¹, Alice Tirard², Alexandra-Chloé Villani³

Affiliations

¹ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH, UK; Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
² Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
³ Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: avillani@mgh.harvard.edu.

PMID: 35263562
DOI: 10.1016/j.immuni.2022.02.011

Abstract

The presumed common origin of plasmacytoid and conventional dendritic cells has been the contentious subject of recent debate. In this issue of Immunity, Feng et al. employed an inducible cell barcoding system to track clonal relationships and uncovered a surprising close developmental relationship between cDC1s and pDCs.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells.
Feng J, Pucella JN, Jang G, Alcántara-Hernández M, Upadhaya S, Adams NM, Khodadadi-Jamayran A, Lau CM, Stoeckius M, Hao S, Smibert P, Tsirigos A, Idoyaga J, Reizis B. Feng J, et al. Immunity. 2022 Mar 8;55(3):405-422.e11. doi: 10.1016/j.immuni.2022.01.016. Epub 2022 Feb 17. Immunity. 2022. PMID: 35180378 Free PMC article.

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Plasmacytoid dendritic cells: Welcome back to the DC fold

Affiliations

Plasmacytoid dendritic cells: Welcome back to the DC fold

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

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MeSH terms

LinkOut - more resources

Full Text Sources