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Review
. 2022 Jun 15;60(6):e0219621.
doi: 10.1128/jcm.02196-21. Epub 2022 Mar 10.

Enhancing Diagnostics in Orthopedic Infections

Eibhlin Higgins  1 , Gina A Suh  1 , Aaron J Tande  1
Affiliations
Review

Enhancing Diagnostics in Orthopedic Infections

Eibhlin Higgins et al. J Clin Microbiol. .

Abstract

Accurate diagnosis of orthopedic infection is crucial in guiding both antimicrobial therapy and surgical management in order to optimize patient outcomes. A variety of microbiological and nonmicrobiological methods are used to establish the presence of a musculoskeletal infection. In this minireview, we examine traditional culture-based and newer molecular methodologies for pathogen detection, as well as systemic and localized assays to assess host response to maximize diagnostic yield.

Keywords: PJI; bone and joint infection; orthopedic infection; osteomyelitis; prosthetic joint infection; septic arthritis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIG 1
FIG 1
Principles of diagnostics in orthopedic infections.
FIG 2
FIG 2
Process of implant sonication.
FIG 3
FIG 3
Plain film (A) demonstrating chronic tibial osteomyelitis with intraosseus abscess. MRI images from the same patient demonstrating intense peripheral enhancement consistent with a granulation layer (B, axial sequence post gadolinium contrast administration) and internal fluid signal (larger arrow) and marked peripheral edema (smaller arrow) again suggestive of intraosseus abscess (C, sagittal T2 fat-saturated sequence).
See this image and copyright information in PMC

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