Impaired functional network properties contribute to white matter hyperintensity related cognitive decline in patients with cerebral small vessel disease

Abstract

Background: White matter hyperintensity (WMH) is one of the typical neuroimaging manifestations of cerebral small vessel disease (CSVD), and the WMH correlates closely to cognitive impairment (CI). CSVD patients with WMH own altered topological properties of brain functional network, which is a possible mechanism that leads to CI. This study aims to identify differences in the characteristics of some brain functional network among patients with different grades of WMH and estimates the correlations between these different brain functional network characteristics and cognitive assessment scores.

Methods: 110 CSVD patients underwent 3.0 T Magnetic resonance imaging scans and neuropsychological cognitive assessments. WMH of each participant was graded on the basis of Fazekas grade scale and was divided into two groups: (A) WMH score of 1-2 points (n = 64), (B) WMH score of 3-6 points (n = 46). Topological indexes of brain functional network were analyzed using graph-theoretical method. T-test and Mann-Whitney U test was used to compare the differences in topological properties of brain functional network between groups. Partial correlation analysis was applied to explore the relationship between different topological properties of brain functional networks and overall cognitive function.

Results: Patients with high WMH scores exhibited decreased clustering coefficient values, global and local network efficiency along with increased shortest path length on whole brain level as well as decreased nodal efficiency in some brain regions on nodal level (p < 0.05). Nodal efficiency in the left lingual gyrus was significantly positively correlated with patients' total Montreal Cognitive Assessment (MoCA) scores (p < 0.05). No significant difference was found between two groups on the aspect of total MoCA and Mini-mental State Examination (MMSE) scores (p > 0.05).

Conclusion: Therefore, we come to conclusions that patients with high WMH scores showed less optimized small-world networks compared to patients with low WMH scores. Global and local network efficiency on the whole-brain level, as well as nodal efficiency in certain brain regions on the nodal level, can be viewed as markers to reflect the course of WMH.

Keywords: Cerebral small vessel disease; Cognitive impairment; Functional network; Graph theoretical analysis; White matter hyperintensity.

Fig. 1

The global and local network efficiency of GroupA and GroupB. GroupA (group of patients with the 1–2 points WMH score, 64 cases). GroupB (group of patients with the 3–6 points WMH score, 46 cases). Two independent sample t test were used for statistical analysis

Fig. 2

Results of alterations in the left-brain network node efficiency between group A and group B. The GroupA = group of patients with the 1–2 points WMH score. The GroupB = group of patients with the 3–6 points WMH score

Fig. 3

Results of alterations in the right-brain network node efficiency between group A and group B. The GroupA = group of patients with the 1–2 points WMH score. The GroupB = group of patients with the 3–6 points WMH score

Fig. 4

The correlation between WMH volume and the efficiency of Postcentral_L