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Observational Study
. 2022 Mar 9;12(1):3812.
doi: 10.1038/s41598-022-07735-x.

Serum catestatin levels in patients with rheumatoid arthritis

Petra Simac  1 , Dijana Perkovic  2 , Ivona Bozic  2 , Marijana Matijas  2 , Katarina Gugo  3 , Dinko Martinovic  4 , Josko Bozic  4
Affiliations
Observational Study

Serum catestatin levels in patients with rheumatoid arthritis

Petra Simac et al. Sci Rep. .

Abstract

Catestatin (CST) is an important peptide that influences various inflammatory diseases. Our goal was to investigate CST concentrations in patients with RA compared to healthy subjects. This cross-sectional observational study included 80 patients with RA and 80 healthy control subjects. Demographic characteristics and laboratory parameters were recorded. Serum CST levels were determined by an enzyme-linked immunosorbent assay (ELISA). Serum CST levels were significantly higher in RA patients than in the control group (10.53 ± 3.90 vs 5.24 ± 2.37 ng/mL, p < 0.001). In RA patients, there was a statistically significant correlation between CST and patient age (r = 0.418, p < 0.001) and both DAS28 (r = 0.469, p < 0.001) and HAQ scores (r = 0.483, p < 0.001). There was a statistically significant correlation between serum CST levels and RA duration (r = 0.583, p < 0.001). Multiple linear regression analysis showed that serum CST levels retained a significant association with RA duration (β ± SE, 0.13 ± 0.04, p = 0.002) and DAS28 score (0.94 ± 0.45, p = 0.039) after model adjustment for age, body mass index (BMI) and HAQ score, with serum CST levels as a dependent variable. These findings imply that CST is possibly associated with RA complex pathophysiology and disease activity. However, future larger multicentric longitudinal studies are necessary to define the role of CST in RA.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Comparison of serum catestatin levels between the RA group (N = 80) and the control group (N = 80). *t-test for independent samples.
Figure 2
Figure 2
Correlation between serum catestatin levels and (a) HAQ score and (b) DAS28 score (N = 80). *Pearson’s correlation coefficient.
Figure 3
Figure 3
Correlation between serum catestatin levels and RA duration (N = 80). *Spearman’s correlation coefficient.
Figure 4
Figure 4
Comparison of serum catestatin levels between RA duration tertiles. *First tertile N = 27; Second tertile N = 26; Third tertile N = 27. One-way analysis of variance (ANOVA) with a post hoc Tukey test was used to examine differences between each of the groups. ap < 0.05 vs first RA duration tertile. bp < 0.05 vs second RA duration tertile.
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