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. 2022 May;19(5):281-282.
doi: 10.1038/s41569-022-00684-y.

The future of cardiac xenotransplantation

David K C Cooper  1 , Richard N Pierson 3rd  2
Affiliations

The future of cardiac xenotransplantation

David K C Cooper et al. Nat Rev Cardiol. 2022 May.

Abstract

Reflecting on the first genetically engineered pig-to-human heart transplantation in this Clinical Outlook article, we discuss the likely future of cardiac xenotransplantation. Initial clinical trials are expected to explore compassionate use as destination therapy in carefully selected adult patients and as a bridge to heart allotransplantation in infant patients with complex congenital heart disease.

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Conflict of interest statement

D.K.C.C. is a consultant for eGenesis, but the opinions expressed in this article are his own and do not necessarily reflect those of the company. D.K.C.C. and R.N.P.III have received research materials and/or funding from eGenesis and Revivicor.

Figures

Fig. 1 |
Fig. 1 |. Major milestones in cardiac xenotransplantation research in the past 4 decades.
The top half of the timeline shows the major immunobiological findings in cardiac xenotransplantation.The bottom half of the timeline depicts the major genetically engineered (GE) pig models forxenotransplantation research. GTKO,al,3-galactosyliransferase knockout; KO, knockout; NHP, non-human primate; TBM, thrombomodulin.
See this image and copyright information in PMC

References

    1. Cooper DKC et al. Justification of specific genetic modifications in pigs for clinical organ xenotransplantation. Xenotransplantation 26, e12516 (2019). - PMC - PubMed
    1. Langin M et al. Consistent success in life-supporting porcine cardiac xenotransplantation. Nature 564, 430–433 (2018). - PubMed
    1. Goerlich CH et al. The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors. J. Thorac. Cardiovasc. Surg 10.1016/j.jtcvs.2021.07.051 (2021). - DOI - PMC - PubMed
    1. Buhlei L et al. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation 69, 2296–2304 (2000). - PubMed
    1. Yamamoto I et al. Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout). Sci. Rep 10, 9771 (2020). - PMC - PubMed

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