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. 2022 Mar 3:15:685-694.
doi: 10.2147/DMSO.S350518. eCollection 2022.

Effect of Anagliptin versus Sitagliptin on Renal Function: Subanalyzes from the REASON Trial

Hiroki Teragawa  1 , Takeshi Morimoto  2 , Yuichi Fujii  1 , Tomohiro Ueda  1 , Mio Sakuma  2 , Michio Shimabukuro  3 , Osamu Arasaki  4 , Koichi Node  5 , Takashi Nomiyama  6 , Shinichiro Ueda  7
Affiliations

Effect of Anagliptin versus Sitagliptin on Renal Function: Subanalyzes from the REASON Trial

Hiroki Teragawa et al. Diabetes Metab Syndr Obes. .

Abstract

Purpose: The effects of two types of dipeptidyl peptidase-4 (DPP-4) inhibitors on renal function remain unclear. Thus, we investigated the effect of anagliptin (ANA) and sitagliptin (SITA) on renal function in patients with type 2 diabetes who participated in the randomized evaluation of ANA versus SITA on low-density lipoprotein-cholesterol (LDL-C) in diabetes (REASON) trial.

Patients and methods: We measured the estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR) before and after the REASON trial. ANA 200 mg/day was administered to 177 patients for 52 weeks, while SITA 50 mg/day was given to 176 patients. We investigated the relationship between differences in renal function and differences in hemoglobin A1c (HbA1c) levels, LDL-C levels, and blood pressure (BP).

Results: No significant differences were found in baseline eGFR and UACR between the two groups. The eGFR levels were significantly decreased in both groups; however, the UACR level was unchanged in the ANA group but elevated in the SITA group, although the difference did not reach significance between the two groups. The difference in eGFR was affected by the differences in HbA1c level and BP, and the difference in the UACR was affected by the differences in LDL-C level and BP, which were reduced only in the ANA group.

Conclusion: These findings imply that the effects of DPP-4 inhibitors on renal function, especially on UACR, may be different between the types of DPP-4 inhibitors.

Keywords: albuminuria; dipeptidyl peptidase 4; dipeptidyl peptidase 4 inhibitors; glomerular filtration rate.

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Conflict of interest statement

Dr H.T. reports lecturer fees from Daichi Sankyo, Mitsubish Tanabe, Bayer, Kowa, and Nihon Medi-Physics. Dr. T.M. has lecturer fees from AbbVie, AstraZeneca, Daiichi Sankyo, Japan Lifeline, Kowa, Toray, Tsumura, Kyorin, Mitsubishi Tanabe, Pfizer, and Bayer, as well as manuscript payments from Pfizer and advisory board roles with Asahi Kasei, Boston Scientific, Bristol-Myers Squibb, and Novartis. Dr. Y.F. and T.U. declare that they have no competing interests. Dr. M.S. is a member of Enomoto Pharmaceutical’s advisory board. Dr. M.S. has received research grants from AstraZeneca, Ono, and Sanwa Kagaku Kenkyusho, as well as nonpurpose research grants from Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Chugai, Eli Lilly, Kowa, Mitsubishi Tanabe, MSD, Novo Nordisk, Ono, Taisho Toyama, and Takeda; lecturer fees from Astella. Dr O.A. reports lecturer fees from Abbott, Astellas, Boehringer Ingelheim, Medtronic, and St. Jude Medical. Dr. K.N. reports research grants from Abbott, Actelion, Air Water, Asahi Kasei, Astellas, Bayer, Terumo, Boehringer Ingelheim Japan, Mochida Pharmaceutical, Fuji Yakuhin, Medtronic, Daiichi Sankyo, Eli Lilly Japan, Takeda Pharmaceutical, GlaxoSmithKline, Mebix, Mitsubishi Tanabe, MSD, Novartis, Novo Nordia, Ono Pharmaceutical, and Teijin; nonpurpose research grants from Abbott, Astellas, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb. Dr. T.N. has received research grants from Eli Lilly, Mitsubishi Tanabe, MSD, Novartis, Novo Nordisk, Ono, Sanofi, Sanwa Kagaku Kenkyusho, Sumitomo Dainippon, Taisho Toyama, Takeda, and Terumo, as well as lecturer fees from Arkray, Astellas, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Johnson & Johnson Dr. S.U. has received research funding from Bristol-Myers Squibb and Kowa, as well as non-purpose research grants from Bristol-Myers Squibb, Chugai, MSD, Pfizer, and Takeda. He also has lecturer fees from Boehringer Ingelheim and MSD. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Changes in the estimated glomerular filtration rate (eGFR) and urinary albumin–creatinine ratio (UACR) in the anagliptin (ANA) and sitagliptin (SITA) groups. The bars indicate the standard errors.
Figure 2
Figure 2
Subgroup analyses of the difference in the estimated glomerular filtration rate (eGFR).
Figure 3
Figure 3
Subgroup analyses of the difference in the urinary albumin–creatinine ratio (UACR).
See this image and copyright information in PMC

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