Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 21:13:823919.
doi: 10.3389/fneur.2022.823919. eCollection 2022.

Brain Activity Changes in Slow 5 and Slow 4 Frequencies in Patients With Optic Neuritis: A Resting State Functional MRI Study

Kai Yan  1 , Wen-Qing Shi  2 , Ting Su  3 , Xu-Lin Liao  4 , Shi-Nan Wu  2 , Qiu-Yu Li  2 , Jing Yu  5 , Hui-Ye Shu  2 , Li-Juan Zhang  2 , Yi-Cong Pan  2 , Yi Shao  2
Affiliations

Brain Activity Changes in Slow 5 and Slow 4 Frequencies in Patients With Optic Neuritis: A Resting State Functional MRI Study

Kai Yan et al. Front Neurol. .

Abstract

Objective: We used the amplitude of low-frequency fluctuation (ALFF) method to investigate spontaneous brain activity in patients with optic neuritis (ON) in specific frequency bands.

Data and methods: A sample of 21 patients with ON (13 female and eight male) and 21 healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) scans in the resting state. We analyzed the ALFF values at different frequencies (slow-4 band: 0.027-0.073 Hz; slow-5 band: 0.01-0.027 Hz) in ON patients and HCs.

Results: In the slow-4 frequency range, compared with HCs, ON patients had apparently lower ALFF in the insula and the whack precuneus. In the slow-5 frequency range, ON patients showed significantly increased ALFF in the left parietal inferior and the left postcentral.

Conclusion: Our results suggest that ON may be involved in abnormal brain function and can provide a basis for clinical research.

Keywords: amplitude of low-frequency fluctuation; functional magnetic resonance imaging; optic neuritis; resting state; slow 5 and slow 4 frequencies.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer HL declared a shared parent affiliation with several of the authors, W-QS, S-NW, Q-YL, H-YS, L-JZ, Y-CP and YS at the time of review.

Figures

Figure 1
Figure 1
Example of optic neuritis observed using a FC and FFA. FC, fundus camera; FFA, fluorescence fundus angiography.
Figure 2
Figure 2
Frequency-associated ALFF analyses between the ON and HC groups. (A) Main effects of group, (B) main effects of frequency band, and (C) their interactions, with Gaussian random field theory correction, voxel-level P < 0.01 and cluster-level P < 0.05. Compared with HC, red represents the brain areas with increased AlFF, and blue represents the brain areas with decreased AlFF in patients with ON. ALFF, amplitude of low-frequency fluctuation; ON, optic neuritis; L, left; HC, healthy control; R, right.
Figure 3
Figure 3
Difference in the ALFF values in the brain between the ON and HC groups across slow-4 (A) and slow-5 (B) frequencies, with Gaussian random field theory correction, voxel-level P < 0.01 and cluster-level P < 0.05. Compared with HC, red represents the brain areas with increased AlFF, and blue represents the brain areas with decreased AlFF in patients with ON. ALFF, amplitude of low-frequency fluctuation; ON, optic neuritis; L, left; HC, healthy control; R, right.
Figure 4
Figure 4
The mean ALFF values of altered brain regions between the ON and HCs. ALFF, amplitude of low-frequency fluctuation; ON, optic neuritis; HCs, healthy controls.
Figure 5
Figure 5
Correlations between the mean ALFF values and the clinical behaviors. (A) The HADS scores showed a negative correlation with the ALFF value of the slow-4 band in the left precuneus (r = −0.974, P < 0.001), and (B) the HADS scores showed a negative correlation with the ALFF value of the slow-4 band in the left parietal inf (r = −0.762, P < 0.001). ALFF, amplitude of low-frequency fluctuation; HADS, hospital anxiety and depression scale.
Figure 6
Figure 6
Correlations between mean ALFF values and behavioral performance. Compared with the HCs, the ALFF value of the left precuneus was decreased in ON. And the patients with ON exhibited with more depression and anxiety. ALFF, amplitude of low-frequency fluctuation; HCs, healthy controls; ON, optic neuritis.
See this image and copyright information in PMC

References

    1. Beck RW, Gal RL. Treatment of acute optic neuritis: a summary of findings from the optic neuritis treatment trial. Arch Ophthalmol. (2008) 126:994–5. 10.1001/archopht.126.7.994 - DOI - PMC - PubMed
    1. Vedula SS, Brodney-Folse S, Gal RL, Beck R. Corticosteroids for treating optic neuritis. Cochrane Database Syst Rev. (2007) 24:CD001430. 10.1002/14651858.CD001430.pub2 - DOI - PMC - PubMed
    1. Wakakura M, Ishikawa S, Oono S, Tabuchi A, Kani K, Tazawa Y, et al. . [Incidence of acute idiopathic optic neuritis and its therapy in Japan. Optic Neuritis Treatment Trial Multicenter Cooperative Research Group (ONMRG)]. Nippon Ganka Gakkai Zasshi. (1995) 99:93–7. - PubMed
    1. MacDonald BK, Cockerell OC, Sander JW, Shorvon SD. The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain. (2000) 123:665–76. 10.1093/brain/123.4.665 - DOI - PubMed
    1. Wilhelm H, Schabet M. The diagnosis and treatment of optic neuritis. Dtsch Arztebl Int. (2015) 112:616–25. 10.3238/arztebl.2015.0616 - DOI - PMC - PubMed

LinkOut - more resources