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. 2022 Feb 2:15:100235.
doi: 10.1016/j.vas.2022.100235. eCollection 2022 Mar.

Aspects in controlled drug delivery for topical applications in veterinary medicine

Eran Lavy  1 , David Kirmayer  2 , Zakhar Nudelman  1 , Liya Orenshtein-Vilensky  3 , Timothy G Rowan  4 , Julia Shenderovich-Gefter  2   5 , Michael Friedman  2
Affiliations

Aspects in controlled drug delivery for topical applications in veterinary medicine

Eran Lavy et al. Vet Anim Sci. .

Abstract

The controlled release of drugs is an appealing area of research as it provides numerous benefits in veterinary and human medicine. In this paper we attempt to analyze certain aspects related to topical drug delivery systems, their successes and failures, and their place in veterinary medicine. Some emphasis is given to the pharmaceutical aspects of the delivery systems, where the material available made it possible. Purely topical devices, such as cattle ear tags and various collars, as well as some topically administered bioavailable delivery systems are discussed. Special attention is given to hitherto under-evaluated delivery systems, such as topical varnishes. A carefully selected bibliography aims to lead the reader easily to the facts, without providing overwhelming data of varying quality. We believe that the paper may be of interest to practicing veterinarians as well as to pharmaceutical scientists working or considering practice in the area.

Keywords: Controlled release; Spot-on; Topical; Varnish; Veterinary; Wearable.

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Conflict of interest statement

The authors declare no competing interests.

References

    1. Acton A.E., Beale A.B., Gilger B.C., Stoskopf M.K. Sustained release cyclosporine therapy for bilateral keratoconjunctivitis sicca in a red wolf (Canis rufus) Journal of Zoo and Wildlife Medicine. 2006:562–564. - PubMed
    1. Ahrens E. Horn fly control with an insecticide-impregnated ear tag. Southwestern Entomologist. 1977;2(1):8–10. - PubMed
    1. Ahrens E., Cocke J. Season long horn fly control with an insecticide-impregnated ear tag. Journal of Economic Entomology. 1979;72(2):215. -215. - PubMed
    1. Alany R.G., Bhattarai S., Pranatharthiharan S., Devarajan P.V. Intramammary delivery technologies for cattle mastitis treatment. In Long Acting Animal Health Drug Products. 2013:295–327.
    1. Andreoni V., Giorgi M. Evaluation of plasma detectable concentrations of two lidocaine transdermal formulations and their analgesic effect in the horse. Journal of Equine Veterinary Science. 2009;29(9):681–686.

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