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Review
. 2022 Feb 23;14(5):876.
doi: 10.3390/polym14050876.

The Molecular Interaction of Collagen with Cell Receptors for Biological Function

Jeevithan Elango  1   2 , Chunyu Hou  1 , Bin Bao  1 , Shujun Wang  3 , José Eduardo Maté Sánchez de Val  2 , Wu Wenhui  1
Affiliations
Review

The Molecular Interaction of Collagen with Cell Receptors for Biological Function

Jeevithan Elango et al. Polymers (Basel). .

Abstract

Collagen, an extracellular protein, covers the entire human body and has several important biological functions in normal physiology. Recently, collagen from non-human sources has attracted attention for therapeutic management and biomedical applications. In this regard, both land-based animals such as cow, pig, chicken, camel, and sheep, and marine-based resources such as fish, octopus, starfish, sea-cucumber, and jellyfish are widely used for collagen extraction. The extracted collagen is transformed into collagen peptides, hydrolysates, films, hydrogels, scaffolds, sponges and 3D matrix for food and biomedical applications. In addition, many strategic ideas are continuously emerging to develop innovative advanced collagen biomaterials. For this purpose, it is important to understand the fundamental perception of how collagen communicates with receptors of biological cells to trigger cell signaling pathways. Therefore, this review discloses the molecular interaction of collagen with cell receptor molecules to carry out cellular signaling in biological pathways. By understanding the actual mechanism, this review opens up several new concepts to carry out next level research in collagen biomaterials.

Keywords: biological function; cell signal; collagen; receptors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Collagen integrin signals in the normal physiological function of cells.
Figure 2
Figure 2
Collagen integrin signals in cardiac hypertrophic gene expression.
Figure 3
Figure 3
Collagen integrin signals in cancer.
Figure 4
Figure 4
Collagen DDR signals in cell proliferation and survival.
Figure 5
Figure 5
Collagen DDR signals in ECM deposition.
Figure 6
Figure 6
Collagen DDR signals in cancer.
Figure 7
Figure 7
Collagen DDR signals in EMT.
Figure 8
Figure 8
Collagen GPVI signals in platelets activation and ROS production.
Figure 9
Figure 9
Collagen Oscar signals in bone.
Figure 10
Figure 10
Collagen LAIR1 signals in immune tolerance.
See this image and copyright information in PMC

References

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