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Review
. 2022 Feb 28;14(5):1028.
doi: 10.3390/nu14051028.

Understanding Cystic Fibrosis Comorbidities and Their Impact on Nutritional Management

Dhiren Patel  1 , Albert Shan  2 , Stacy Mathews  2 , Meghana Sathe  3
Affiliations
Review

Understanding Cystic Fibrosis Comorbidities and Their Impact on Nutritional Management

Dhiren Patel et al. Nutrients. .

Abstract

Cystic fibrosis (CF) is a chronic, multisystem disease with multiple comorbidities that can significantly affect nutrition and quality of life. Maintaining nutritional adequacy can be challenging in people with cystic fibrosis and has been directly associated with suboptimal clinical outcomes. Comorbidities of CF can result in significantly decreased nutritional intake and intestinal absorption, as well as increased metabolic demands. It is crucial to utilize a multidisciplinary team with expertise in CF to optimize growth and nutrition, where patients with CF and their loved ones are placed in the center of the care model. Additionally, with the advent of highly effective modulators (HEMs), CF providers have begun to identify previously unrecognized nutritional issues, such as obesity. Here, we will review and summarize commonly encountered comorbidities and their nutritional impact on this unique population.

Keywords: comorbidities; cystic fibrosis; feeding difficulties; growth and development; multidisciplinary care; nutrition; patient outcomes.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Ratchford T.L., Teckman J.H., Patel D.R. Gastrointestinal pathophysiology and nutrition in cystic fibrosis. Expert Rev. Gastroenterol. Hepatol. 2018;12:853–862. doi: 10.1080/17474124.2018.1502663. - DOI - PubMed
    1. Sullivan J.S., Mascarenhas M.R. Nutrition: Prevention and management of nutritional failure in Cystic Fibrosis. J. Cyst. Fibros. 2017;16:S87–S93. doi: 10.1016/j.jcf.2017.07.010. - DOI - PubMed
    1. Borowitz D., Baker R.D., Stallings V. Consensus report on nutrition for pediatric patients with cystic fibrosis. J. Pediatr. Gastroenterol. Nutr. 2002;35:246–259. doi: 10.1097/00005176-200209000-00004. - DOI - PubMed
    1. Tipirneni K.E., Woodworth B.A. Medical and Surgical Advancements in the Management of Cystic Fibrosis Chronic Rhinosinusitis. Curr. Otorhinolaryngol. Rep. 2017;5:24–34. doi: 10.1007/s40136-017-0139-3. - DOI - PMC - PubMed
    1. Alvo A., Villarroel G., Sedano C. Neonatal nasal obstruction. Eur. Arch. Otorhinolaryngol. 2021;278:3605–3611. doi: 10.1007/s00405-020-06546-y. - DOI - PubMed