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Review
. 2022 Feb 25;12(5):589.
doi: 10.3390/ani12050589.

Serum Amyloid A as a Promising Biomarker in Domestic Animals' Reproduction: Current Knowledge and Future Perspective

Marilena Bazzano  1 , Andrea Marchegiani  1 , Alessandro Troisi  1 , Amy McLean  2 , Fulvio Laus  1
Affiliations
Review

Serum Amyloid A as a Promising Biomarker in Domestic Animals' Reproduction: Current Knowledge and Future Perspective

Marilena Bazzano et al. Animals (Basel). .

Abstract

The investigation of acute phase proteins in veterinary medicine has opened the doors towards the identification and use of new markers for a timely assessment of health status in both companion and food-producing animals. The aim of this paper is to review the literature available on the use of serum amyloid A (SAA), an acute phase protein, for the diagnosis and monitoring of reproductive disorders in animals. This review critically appraises the usefulness of such marker in clinical practice and summarizes the current state of knowledge. Recent advances in the diagnosis and monitoring of reproductive diseases are presented, highlighting where SAA evaluation may enhance early diagnostic tools for dogs, cats, cattle, and equines.

Keywords: acute phase protein; bitch; cow; endometritis; mare; mastitis; serum amyloid A.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Myers M.J., Smith E.R., Turfle P.G. Biomarkers in Veterinary Medicine. Annu. Rev. Anim. Biosci. 2017;5:65–87. doi: 10.1146/annurev-animal-021815-111431. - DOI - PubMed
    1. Mobasheri A., Cassidy J.P. Biomarkers in veterinary medicine: Towards targeted, individualised therapies for companion animals. Vet. J. 2010;185:1–3. doi: 10.1016/j.tvjl.2010.04.003. - DOI - PubMed
    1. Petersen H., Nielsen J., Heegaard P. Application of acute phase protein measurements in veterinary clinical chemistry. Vet. Res. 2004;35:163–187. doi: 10.1051/vetres:2004002. - DOI - PubMed
    1. Jain S., Gautam V., Naseem S. Acute-phase proteins: As diagnostic tool. J. Pharm. Bioallied Sci. 2011;3:118. doi: 10.4103/0975-7406.76489. - DOI - PMC - PubMed
    1. Cray C., Zaias J., Altman N.H. Acute phase response in animals: A review. Comp. Med. 2009;59:517–526. - PMC - PubMed