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. 2022 Feb 25;11(5):1265.
doi: 10.3390/jcm11051265.

The Usefulness of Vanin-1 and Periostin as Markers of an Active Autoimmune Process or Renal Fibrosis in Children with IgA Nephropathy and IgA Vasculitis with Nephritis-A Pilot Study

Małgorzata Mizerska-Wasiak  1 , Emilia Płatos  2 , Karolina Cichoń-Kawa  1 , Urszula Demkow  3 , Małgorzata Pańczyk-Tomaszewska  1
Affiliations

The Usefulness of Vanin-1 and Periostin as Markers of an Active Autoimmune Process or Renal Fibrosis in Children with IgA Nephropathy and IgA Vasculitis with Nephritis-A Pilot Study

Małgorzata Mizerska-Wasiak et al. J Clin Med. .

Abstract

This study aimed to evaluate the usefulness of vanin-1 and periostin in urine as markers of the autoimmune process in kidneys and renal fibrosis in IgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAVN). From a group of 194 patients from the Department of Pediatrics and Nephrology, who were included in the Polish Pediatric Registry of IgAN and IgAVN, we qualified 51 patients (20 with IgAN and 31 with IgAVN) between the ages of 3 and 17, diagnosed based on kidney biopsy, for inclusion in the study. All of the patients received glucocorticosteroids, immunosuppressive drugs, or renoprotective therapy. The control group consisted of 18 healthy individuals. The concentration of vanin was significantly higher in the IgAN and IgAVN groups than in the control group. The concentration of vanin/creatinine correlates positively with the level of IgA and negatively with the serum level of C3 at the end of the observation. Urinary vanin-1 concentration may be useful as a marker of the active autoimmune process in IgAN and IgAVN in children, but the study needs confirmation on a larger group of children, along with evaluation of the dynamics of this marker. Urinary periostin is not a good marker for children with IgAN and IgAVN, especially in stage 1 and 2 CKD.

Keywords: IgA nephropathy; IgA vasculitis with nephritis; biomarker; children; periostin; vanin-1.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flow diagram of the study.
Figure 2
Figure 2
The concentration of vanin and vanin/creatinine in urine samples in children with IgAN, IgAVN, and in the control group. (a) The concentration of vanin in urine samples in IgAN, IgAVN and control group; (b) The concentration of vanin/creatinine in urine samples in IgAN, IgAVN and control group.
Figure 3
Figure 3
The concentration of periostin and periostin/creatinine in the urine samples in children with IgAN, IgAVN, and in the control group. (a) The concentration of periostin in urine samples in IgAN, IgAVN and control group; (b) The concentration of periostin/creatinine in urine samples in IgAN, IgAVN and control group.
Figure 4
Figure 4
Correlation of vanin with serum IgA.
Figure 5
Figure 5
Correlation of urinary vanin with serum C3.
See this image and copyright information in PMC

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