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. 2022 Mar 4;11(5):1422.
doi: 10.3390/jcm11051422.

Epidemiological Trends in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair over the Last Decade: Functional vs. Structural Mitral Regurgitation

Leonhard Schneider  1 , Nicoleta Nita  1 , Tilman Dahme  1 , Sinisa Markovic  1 , Mirjam Keßler  1 , Wolfang Rottbauer  1 , Marijana Tadic  1
Affiliations

Epidemiological Trends in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair over the Last Decade: Functional vs. Structural Mitral Regurgitation

Leonhard Schneider et al. J Clin Med. .

Abstract

Objective: We aimed to investigate the demographic, clinical and hemodynamic characteristics of patients who underwent percutaneous mitral valve (MV) repair over the last decade, as well as to determine the potential changes in trends of these parameters among patients with structural and functional MR (SMR and FMR).

Methodology: We analyzed all patients who underwent interventional MV repair in our institution between January 2010 and March 2021. Our study included both SMR and FMR patients. All data were obtained from a local registry.

Results: Nine hundred and seventeen patients (357 SMR patients and 563 FMR patients) were involved in this study. We did not find significant differences in demographical, clinical and hemodynamic characteristics among SMR and FMR patients. Left ventricular remodeling and systolic dysfunction were more pronounced in FMR patients. Systemic vascular resistance was the only hemodynamic parameter that differed between SMR and FMR patients; it was higher in SMR group. An evaluation of the trend between the first and last five years of our experience revealed that the number of patients treated with this technique is constantly increasing, but that this is more pronounced in SMR patients. It was also found that the operative risk of SMR and FMR patients was significantly higher in the first five years. Additionally, our results showed change in medical therapy in MR patients over the last decade in terms of increased use of angiotensin II receptor blockers and the introduction of angiotensin receptor II blocker-neprilysin inhibitor.

Conclusion: SMR and FMR patients who underwent interventional MV repair have similar clinical and hemodynamic characteristics. The percentage of SMR patients increased more significantly than FMR patients over the last five years.

Keywords: epidemiology; interventional mitral valve repair; mitral regurgitation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Patients who underwent MR TEER between 2010 and 2021. MR—mitral regurgitation, N—number, TEER—transcatheter edge-to-edge repair.
Figure 2
Figure 2
Therapy at baseline.
Figure 3
Figure 3
Differences in left ventricular ejection fraction (LVEF) between patients with structural and functional mitral regurgitation (MR).
Figure 4
Figure 4
The difference in prevalence of patients with New York Heart Association (NYHA) class III and IV in patients with functional and structural mitral regurgitation (MR) between two periods (2010–2015 and 2016–2021).
See this image and copyright information in PMC

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