Cranberry: Chemical Composition, Antioxidant Activity and Impact on Human Health: Overview
- PMID: 35268605
- PMCID: PMC8911768
- DOI: 10.3390/molecules27051503
Cranberry: Chemical Composition, Antioxidant Activity and Impact on Human Health: Overview
Abstract
Cranberries are a rich source of bioactive compounds that comprise a healthy diet. Cranberry is abundant in nutritional components and many bioactive compounds that have antioxidant properties. Both American (Vaccinium macrocarpon) and European (Vaccinium oxycoccus) cranberry species are rich in polyphenols such as phenolic acids, anthocyanins and flavonoids, and is one of the few fruits that is high in proanthocyanidins, which is linked to many health benefits. The review systematizes information on the chemical composition of cranberry, its antioxidant effect, and the beneficial impact on human health and disease prevention after cranberry consumption, and in particular, its effect against urinary tract inflammation with both adults and children, cardiovascular, oncology diseases, type 2 diabetes, metabolic syndrome, obesity, tooth decay and periodontitis, Helicobacter pylori bacteria in the stomach and other diseases. Additional research needs to study cranberry proteomics profiling, polyphenols interaction and synergism with other biologically active compounds from natural ingredients and what is important in formulation of new functional foods and supplements.
Keywords: anthocyanins; antioxidant; cranberry; polyphenols; proanthocyanidins; urinary tract infection.
Conflict of interest statement
The authors declare no conflict of interest.
Similar articles
-
Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos).Molecules. 2018 Dec 21;24(1):24. doi: 10.3390/molecules24010024. Molecules. 2018. PMID: 30577610 Free PMC article. Review.
-
Fruit Physical Features, Phenolic Compounds Profile and Inhibition Activities of Cranberry Cultivars (Vaccinium macrocarpon) Compared to Wild-Grown Cranberry (Vaccinium oxycoccus).Plant Foods Hum Nutr. 2019 Sep;74(3):300-306. doi: 10.1007/s11130-019-00737-7. Plant Foods Hum Nutr. 2019. PMID: 31098879 Free PMC article.
-
Cranberry proanthocyanidins: natural weapons against periodontal diseases.J Agric Food Chem. 2012 Jun 13;60(23):5728-35. doi: 10.1021/jf203304v. Epub 2011 Nov 29. J Agric Food Chem. 2012. PMID: 22082264 Review.
-
Comparison of health-relevant flavonoids in commonly consumed cranberry products.J Food Sci. 2012 Aug;77(8):H176-83. doi: 10.1111/j.1750-3841.2012.02788.x. Epub 2012 Jul 2. J Food Sci. 2012. PMID: 22747948
-
Bioactive compounds in cranberries and their biological properties.Crit Rev Food Sci Nutr. 2010 Aug;50(7):666-79. doi: 10.1080/10408390903044107. Crit Rev Food Sci Nutr. 2010. PMID: 20694928 Review.
Cited by
-
Plant phenolics inhibit focal adhesion kinase and suppress host cell invasion by uropathogenic Escherichia coli.Infect Immun. 2024 May 7;92(5):e0008024. doi: 10.1128/iai.00080-24. Epub 2024 Mar 27. Infect Immun. 2024. PMID: 38534100 Free PMC article.
-
Cranberry: A Promising Natural Product for Animal Health and Performance.Curr Issues Mol Biol. 2025 Jan 27;47(2):80. doi: 10.3390/cimb47020080. Curr Issues Mol Biol. 2025. PMID: 39996801 Free PMC article. Review.
-
Principal Component Analysis Followed by Mahalanobis Distance Classification for Authentication of Vaccinium Berry Ingredients and Supplements via LC-MS/MS-based Anthocyanin Fingerprinting.Anal Chem. 2025 Jul 1;97(25):12971-12980. doi: 10.1021/acs.analchem.4c06037. Epub 2025 Jun 16. Anal Chem. 2025. PMID: 40524465 Free PMC article.
-
The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients. 2024 Mar 9;16(6):782. doi: 10.3390/nu16060782. Nutrients. 2024. PMID: 38542695 Free PMC article.
-
The Protective Role of Cranberries and Blueberries in Oral Cancer.Plants (Basel). 2023 Jun 15;12(12):2330. doi: 10.3390/plants12122330. Plants (Basel). 2023. PMID: 37375955 Free PMC article. Review.
References
-
- Caruso F.L., Bristow P.R., Oudemans P.V. Cranberries: The Most Intriguing Native American Fruit. Phytopathology News. 2021. [(accessed on 21 September 2021)]. Available online: https://www.aspnet.org/edcenter/apsnetfeatures/Pages/Cranberries.aspx.
-
- Cape Cod Cranberry Grower’s Association. 2021. [(accessed on 21 September 2021)]. Available online: https://www.cranberries.org.
-
- Česonienė L., Daubaras R. Phytochemical composition of the large cranberry (Vaccinium macrocarpon) and the small cranberry (Vaccinium oxycoccos) In: Simmonds M.S.J., Preedy V.R., editors. Nutritional Composition of Fruit. Academic Press; Cambridge, MA, USA: 2016. pp. 173–194. Chapter 8. - DOI
-
- Česonienė L., Daubarus R., Paulauskas A., Žukauskiene J., Zych M. Morphological and genetic diversity of European cranberry (Vaccinium oxycoccos L., Ericaceae) clones in Lithuanian reserves. Acta Soc. Bot. Pol. 2013;82:211–217. doi: 10.5586/asbp.2013.026. - DOI
-
- The Cranberry Institute About Cranberries. 2021. [(accessed on 21 September 2021)]. Available online: https://www.cranberryinstitute.org/about-cranberries.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical